Real-World Experience with Enhanced Monofocal Intraocular Lenses Following Cataract Surgery: A Multicenter Retrospective Case Series

The enVista Aspire (EA) and enVista Aspire Toric (ETA) lenses are monofocal intraocular lenses (IOLs) with intermediate-optimized optics designed to broaden depth of focus. This study describes outcomes with these IOLs in real-world clinical practice. This multicenter, retrospective, real-world case series study included six cataract surgeons in the USA. Surgeons provided a convenience sample of ≥ 5 study IOL implantation cases and completed a retrospective experience survey. Outcomes included visual acuity (corrected and uncorrected distance visual acuity [CDVA, UDVA] and uncorrected intermediate visual acuity [UIVA]), refractive outcomes, and safety (adverse events and visual changes). The surgeon survey captured IOL utilization patterns and surgeon experience as supplementary descriptive findings. The analysis included 141 eyes (88 EA and 53 ETA) from 84 patients. Patients were aged 62–84 years, with postoperative follow-up ranging from approximately Days 1–6 to 4 months. At the last available postoperative visit, monocular CDVA of 20/25 or better was achieved by 97.2% of EA and 94.9% of ETA eyes; monocular UDVA of 20/25 or better by 71.3% and 84.9%, respectively; and monocular UIVA of 20/32 or better by 76.6% and 93.0%, respectively. A binocular UIVA of 20/32 or better was achieved by 100% of patients. Mean ± SD SEQ outcome was −0.06 ± 0.30 D (EA) and 0.00 ± 0.32 D (ETA). No serious adverse events were documented in the available records. Findings from the surgeon survey indicated positive surgeon experience with the qualities and outcomes of the study IOLs. In this descriptive real-world analysis, a high proportion of eyes implanted with the study IOLs achieved good distance and functional intermediate vision. Cataracts are a common part of aging. They can cause blurred vision and sight loss. Cataract surgery removes the cloudy natural lens from the eye and replaces it with an artificial intraocular lens (IOL). Standard monofocal IOLs provide good distance vision but do not support clear vision at intermediate distances, which is required for activities such as using a computer or cooking. “Enhanced monofocal” IOLs are designed to improve intermediate vision while maintaining the visual quality of standard monofocal IOLs. The main aim of the study was to describe how the enVista Aspire and enVista Aspire Toric IOLs (used in patients with astigmatism) performed in everyday clinical practice across six eye care centers in the USA. Surgeons completed forms using information from medical records of patients who received these lenses. Outcomes included distance and intermediate vision after surgery, how closely vision after surgery matched the planned outcome, and whether any safety issues occurred. The results showed that a high proportion of eyes had good distance vision and usable intermediate vision after surgery. Vision after surgery was generally close to the planned outcome, meaning many patients achieved the intended level of vision correction. No serious adverse events were documented in the available clinical records. This study provides early real-world observations on visual and safety outcomes with enhanced monofocal IOLs in routine cataract surgery.