A transient mitochondrial switch underlies long lasting effects of adolescent cannabis
Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 during adolescence, identifying mitochondrial pathways as causal mechanisms and potential therapeutic targets to reduce their long-term consequences.
Authors
- Irene Manzanares-Sierra (ORCID: https://orcid.org/0009-0006-2461-5167)
- Arnau Busquets-García (ORCID: https://orcid.org/0000-0002-7100-8873)
- Guillaume Ferreira (ORCID: https://orcid.org/0000-0001-5984-8143)
- Darío García-Rodríguez (ORCID: https://orcid.org/0000-0001-5416-130X)
- Christina Ioannidou (ORCID: https://orcid.org/0000-0003-2726-0403)
- Martina Di Bartolomeo (ORCID: https://orcid.org/0000-0003-4266-7607)
- Daniel Jiménez-Blasco (ORCID: https://orcid.org/0000-0002-1384-1832)
- Giovanni Marsicano (ORCID: https://orcid.org/0000-0003-3804-1951)
- Juan P. Bolaños (ORCID: https://orcid.org/0000-0002-3949-6862)
- Israel Manjarrés-Raza (ORCID: https://orcid.org/0000-0001-6314-9839)
- Antonio C. Pagano Zottola
- Francisca Julio-Kalajzić
Institutions
- University of Teramo (IT)
- Université de Bordeaux (FR)
- Inserm (FR)
- Universidad de Salamanca (ES)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Neurocentre Magendie (FR)
- Hospital Del Mar (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- NutriNeuro (FR)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Instituto de Biología Funcional y Genómica (ES)
- Institut Polytechnique de Bordeaux (FR)
Publication Details
- Journal
- Neuropsychopharmacology
- Published
- 2026-08-27
- DOI
- https://doi.org/10.1038/s41386-026-02539-3
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- “la Caixa” Foundation
- European Commission
- Generalitat de Catalunya
- HORIZON EUROPE Framework Programme
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación