The Jumonji HIT: epigenetic control of autoantibodies
In this issue of Blood, Yu et al 1 identify Jumonji domain-containing 1C (Jmjd1c), a histone demethylase, as the first epigenetic regulator shown to restrain spontaneous production of platelet-activating anti-PF4/heparin antibodies that drive heparin-induced thrombocytopenia (HIT) in a mouse model.
Authors
- Freda Passam (ORCID: https://orcid.org/0000-0003-4584-2044)
- José Perdomo (ORCID: https://orcid.org/0000-0002-1554-708X)
Institutions
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
Publication Details
- Journal
- Blood
- Published
- 2026-08-27
- DOI
- https://doi.org/10.1182/blood.2026034449
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00