WNT/β-Catenin–Activated Rosette-Forming Carcinoma With Sarcomatoid Differentiation
ABSTRACT: WNT/β-catenin activated rosette forming carcinoma is a recently described high grade primary cutaneous carcinoma. These tumours, which commonly involve sun-exposed skin in elderly patients, are associated with inactivation of RB1 and mutations in APC or CTNNB1 genes, leading to activation of WNT/β-catenin signalling pathways. We report a case of WNT/β catenin activated rosette forming carcinoma with sarcomatoid differentiation, which has not previously been described.
Authors
- Nima Mesbah Ardakani (ORCID: https://orcid.org/0000-0001-9477-8291)
- Nathan T. Harvey
- Benjamin A. Wood (ORCID: https://orcid.org/0000-0001-6336-0036)
Institutions
- The University of Western Australia (AU)
- Queen Elizabeth II Medical Centre (AU)
- Pathwest Laboratory Medicine (AU)
Publication Details
- Journal
- American Journal of Dermatopathology
- Published
- 2026-08-27
- DOI
- https://doi.org/10.1097/dad.0000000000003412
- Primary Topic
- Cancer and Skin Lesions
- Type
- article
- Field-Weighted Citation Impact
- 0.00