Dichloramine B: A Reagent for Regioselective Chloroalkoxylation of 3‐Aryloxindoles
A catalyst‐ and additive‐free strategy for the direct chloroalkoxylation of 3‐aryloxindoles has been developed using dichloramine B as a readily available electrophilic chlorinating reagent and alcohols as alkoxy nucleophiles. Notably, dichloramine B is converted to benzenesulfonamide during the chloroalkoxylation process, which is regenerated to dichloramine B with Cl 2 in industry. This mild, operationally simple protocol affords aromatic‐chloro‐3‐alkoxyoxindoles with excellent regioselectivity and broad functional‐group tolerance.
Authors
- Zhenhua Jia (ORCID: https://orcid.org/0000-0002-5154-4839)
- Teck‐Peng Loh (ORCID: https://orcid.org/0000-0002-2936-337X)
- Rongbin Hu (ORCID: https://orcid.org/0000-0001-5921-6891)
- Lijuan Liang (ORCID: https://orcid.org/0000-0002-1255-2764)
- Peng Chen (ORCID: https://orcid.org/0000-0002-6252-5772)
- Lina Huang
- Niuniu Li (ORCID: https://orcid.org/0000-0003-0661-7637)
- Dechang Han
Institutions
- Nanyang Technological University (SG)
- Henan University of Technology (CN)
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2026-08-27
- DOI
- https://doi.org/10.1002/adsc.70733
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agency for Science, Technology and Research
- Nanyang Technological University
- National Natural Science Foundation of China
- Henan University of Technology
- Henan University
- Science and Technology Department of Henan Province