The Needle‐Free Frontier: Redefining the Limits of Transdermal Insulin Delivery
Wei and colleagues reported a pH-responsive, charge-switchable polyzwitterionic polymer carrier that achieves non-invasive transdermal insulin delivery without external energy input. The approach leverages adaptive compatibility with the cutaneous microenvironment to shuttle functional macromolecules across intact skin and achieve definitive systemic therapeutic outcomes.
Authors
- Julien Milon Essola
- Xing‐Jie Liang (ORCID: https://orcid.org/0000-0002-4793-1705)
- Junge Chen (ORCID: https://orcid.org/0000-0003-4687-884X)
- Bozhang Xia
- Yuxuan Liu
Institutions
- National Center for Nanoscience and Technology (CN)
- Beijing Advanced Sciences and Innovation Center (CN)
- Beihang University (CN)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Exploration
- Published
- 2026-08-26
- DOI
- https://doi.org/10.1002/exp2.70214
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Nova Program