Harnessing pathogen stress-hormone sensing for living medicines

Pathogens sense host stress hormones in the gut and use them to regulate motility and virulence. A new study in PLOS Biology transfers this pathway to Escherichia coli Nissle and redesigns its regulation to drive programmable outputs.

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Publication Details

Journal
PLoS Biology
Published
2026-08-26
DOI
https://doi.org/10.1371/journal.pbio.3003940
Primary Topic
Stress Responses and Cortisol
Type
article
Field-Weighted Citation Impact
0.00

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article

Harnessing pathogen stress-hormone sensing for living medicines

Weston R. Whitaker
PLoS Biology
Stress Responses and Cortisol
article

Harnessing pathogen stress-hormone sensing for living medicines

Weston R. Whitaker
article en

Abstract

Pathogens sense host stress hormones in the gut and use them to regulate motility and virulence. A new study in PLOS Biology transfers this pathway to Escherichia coli Nissle and redesigns its regulation to drive programmable outputs.

PLoS BiologyVol. 24(8)
Pennsylvania State University (US)
U.S. Department of Agriculture, National Institute of Food and Agriculture
Zero hunger
Openalex Percentile: Top 11%
Stress Responses and Cortisol
DOIOpen Access PDFOpenAlex
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Harnessing pathogen stress-hormone sensing for living medicines — Weston R. Whitaker · PLoS Biology (2026) | TGRS Research Map | TGRS