Insulin-like growth factor–binding protein 7 is a soluble cell adhesion molecule

{"Insulin-like":[0],"growth":[1],"factor-binding":[2],"protein":[3,9],"7":[4],"(IGFBP7)":[5],"is":[6,24,69],"a":[7,49,93,123,133],"secreted":[8],"with":[10],"diverse":[11],"roles":[12],"in":[13,52],"angiogenesis,":[14],"cell":[15,21],"differentiation,":[16],"tissue":[17],"remodeling,":[18],"and":[19,23,104,114,129],"regulating":[20],"signaling":[22,106],"linked":[25],"to":[26,97],"numerous":[27],"human":[28],"diseases.":[29],"The":[30,57],"molecular":[31],"basis":[32],"of":[33,36,55,65,107],"the":[34,53,62,66,72],"multifunctionality":[35],"IGFBP7":[37,46,102],"remains":[38],"unclear.":[39],"Using":[40],"cryo-electron":[41],"microscopy,":[42],"we":[43],"show":[44],"that":[45],"assembles":[47],"into":[48],"barrel-shaped":[50],"dodecamer":[51],"presence":[54],"heparin.":[56],"carboxyl-terminal":[58],"IgC2":[59],"domain":[60,76],"forms":[61],"central":[63],"core":[64],"barrel,":[67],"which":[68],"capped":[70],"by":[71],"amino-terminal":[73],"heparin-binding":[74],"IB":[75],"at":[77],"both":[78],"ends.":[79],"This":[80],"homo-oligomer":[81],"can":[82],"simultaneously":[83],"engage":[84],"heparan":[85],"sulfate":[86],"proteoglycans":[87],"on":[88],"adjacent":[89],"cells,":[90],"functioning":[91],"as":[92,132],"soluble":[94],"\\"cell":[95],"glue\\"":[96],"drive":[98],"cell-cell":[99],"adhesion.":[100],"Furthermore,":[101],"enhances":[103],"prolongs":[105],"receptor":[108,113],"tyrosine":[109],"kinases,":[110],"including":[111],"insulin":[112],"c-MET,":[115],"through":[116],"its":[117],"adhesion":[118,135],"activity.":[119],"These":[120],"findings":[121],"reveal":[122],"structural":[124],"mechanism":[125],"for":[126],"IGFBP7's":[127],"pleiotropy":[128],"establish":[130],"it":[131],"universal":[134],"factor.":[136]}