Sex Differences in Clinical Outcomes After Transcatheter Aortic Valve Implantation ― Insights From a Nationwide Japanese Registry ―
BACKGROUND: Sex differences in outcomes after transcatheter aortic valve implantation (TAVI) for aortic stenosis in Japan have not been fully investigated. METHODS AND RESULTS: increase; 95% confidence interval [CI] 0.77-0.91; P<0.001). Female sex was independently associated with lower risks of in-hospital mortality (aOR 0.60; 95% CI 0.45-0.81) and major RCC transfusion (aOR 0.79; 95% CI 0.71-0.89), but a higher risk of PPI (aOR 1.15; 95% CI 1.02-1.30). CONCLUSIONS: In a Japanese TAVI registry, crude mortality was comparable between the sexes, but women had higher major RCC transfusion and PPI rates. After adjusting for BSA and available measured covariates, female sex was associated with lower in-hospital mortality. Combined sex and BSA assessment appears important for predicting post-TAVI outcomes.
Authors
- Kentaro Mitsui (ORCID: https://orcid.org/0000-0003-1381-7629)
- Hideaki Kanzaki (ORCID: https://orcid.org/0000-0003-3737-0809)
- Kazuhiro Nakao (ORCID: https://orcid.org/0000-0002-9034-3976)
- Satoshi Honda (ORCID: https://orcid.org/0000-0002-1393-4270)
- Takamasa Iwai (ORCID: https://orcid.org/0000-0002-8961-2390)
- Hideo Matama (ORCID: https://orcid.org/0000-0002-7471-3375)
- Masashi Fujino (ORCID: https://orcid.org/0000-0002-2706-4317)
- Yasuhide Asaumi (ORCID: https://orcid.org/0000-0002-9009-7234)
- Koshiro Kanaoka (ORCID: https://orcid.org/0000-0001-7900-7835)
- Atsushi Okada (ORCID: https://orcid.org/0000-0002-0087-4168)
- Kenichiro Sawada (ORCID: https://orcid.org/0009-0000-0710-0870)
- Kota Murai (ORCID: https://orcid.org/0000-0002-5162-4783)
- Shuichi Yoneda
- Teruo Noguchi
- Yoshihiro Miyamoto
- Kazuhiro Yamamoto
- Yoko Sumita
- Yuki Irie
- Kensuke Takagi
- Yu Kataoka
- Kenichi Tsujita
- Satsuki Fukushima
Institutions
- National Cerebral and Cardiovascular Center (JP)
- Health Information Management (BE)
- Kumamoto University (JP)
Publication Details
- Journal
- Circulation Journal
- Published
- 2026-08-26
- DOI
- https://doi.org/10.1253/circj.cj-26-0492
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Cerebral and Cardiovascular Center