GPCR Precision in Addiction Also Requires Ligand, Exposure, and Phenotype Precision
review GPCR heteromerization, biased agonism, and allosteric modulation as routes to more selective addiction therapeutics.Their evidence-graded approach is valuable, but opioid treatment illustrates a complementary translational requirement: precision in the receptor must be matched by precision in the ligand, exposure pattern, clinical phenotype, and treatment setting.
Authors
- Lien‐Chung Wei (ORCID: https://orcid.org/0000-0002-7383-7309)
- Hsin‐Hung Chen
Institutions
- Ministry of Health and Welfare (KR)
- Bali Psychiatric Center (TW)
Publication Details
- Journal
- Drug Development Research
- Published
- 2026-08-26
- DOI
- https://doi.org/10.1002/ddr.70376
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00