Shaping the research agenda of pediatric gastroenterology, hepatology, and nutrition: The proposal from a SIGENP expert groups

Abstract The Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) recognized the need to define research priorities and identify knowledge gaps to guide future investigations in pediatric digestive health. Following international examples, SIGENP aimed to provide a structured framework that aligns scientific innovation with clinical relevance and patient‐centered outcomes. This narrative review represents the consensus output of SIGENP's thematic working groups (WGs) in key fields—inflammatory bowel disease (IBD), Gastrointestinal Endoscopy, Hepatology, Nutrition and Intestinal Failure, Functional and Motility Disorders, and Allergy and Immunity. Each WG conducted a focused review of recent literature, national activities, and registry data, identifying unmet needs and defining strategic objectives. Draft reports were refined through plenary discussions and finalized by consensus during dedicated SIGENP meetings. Across all areas, shared priorities emerged: advancing precision and personalized medicine, integrating multi‐omics and digital tools, and promoting pediatric‐specific evidence through multicenter collaboration and harmonized registries. Disease‐specific gaps include early diagnosis and biomarker discovery in IBD and liver disease, standardization of pediatric endoscopy and motility diagnostics, optimization of nutritional interventions and intestinal failure management, and the exploration of organoid and immune models in celiac disease and food allergy. This review outlines a comprehensive research agenda in pediatric gastroenterology, hepatology, and nutrition developed through a structured SIGENP expert process. It provides a strategic framework to guide future research initiatives, foster collaboration, and ultimately improve outcomes for children with gastrointestinal and nutritional disorders.

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Publication Details

Journal
JPGN Reports
Published
2026-08-25
DOI
https://doi.org/10.1002/jpr3.70228
Primary Topic
Celiac Disease Research and Management
Type
article
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article

Shaping the research agenda of pediatric gastroenterology, hepatology, and nutrition: The proposal from a SIGENP expert groups

Elena Sofia Pieri, Monica Malamisura, Fabiola Di Dato, Renata Auricchio et al.
JPGN Reports
Celiac Disease Research and Management
article

Shaping the research agenda of pediatric gastroenterology, hepatology, and nutrition: The proposal from a SIGENP expert groups

Elena Sofia Pieri, Monica Malamisura, Fabiola Di Dato, Renata Auricchio, Caterina Strisciuglio, Claudio Romano, Carlo Catassi, Renato Tambucci, Luigi Dall’Oglio, Teresa Capriati, Angelo Di Giorgio, Claudia Mandato, Emanuele Nicastro, Paolo Quitadamo, Daniele Alberti, Marco Deganello Saccomani, Valeria Dipasquale, Antonella Diamanti, Giusy Ranucci, Lorenzo Norsa, Licia Pensabene, Salvatore Cucchiara, Ruggiero Francavilla, Luca Scarallo, Maria Immacolata Spagnuolo, Antonio Marseglia, Pietro Vajro, Salvatore Oliva, Maria Elisabetta Baldassarre, Sabrina Cenni, Giuseppe Maggiore, Annamaria Staiano, Paola De Angelis, Flavio Labriola, Sara Renzo, Elena Lionetti, Carlo Agostoni, Silvia Salvatore, Matteo Bramuzzo, Raffaele lorio, Riccardo Troncone, Paolo Lionetti, Luigi Greco, Marco Crocco, Osvaldo Borrelli, Enrico Felici, Valentina Giorgio
article en

Abstract

Abstract The Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) recognized the need to define research priorities and identify knowledge gaps to guide future investigations in pediatric digestive health. Following international examples, SIGENP aimed to provide a structured framework that aligns scientific innovation with clinical relevance and patient‐centered outcomes. This narrative review represents the consensus output of SIGENP's thematic working groups (WGs) in key fields—inflammatory bowel disease (IBD), Gastrointestinal Endoscopy, Hepatology, Nutrition and Intestinal Failure, Functional and Motility Disorders, and Allergy and Immunity. Each WG conducted a focused review of recent literature, national activities, and registry data, identifying unmet needs and defining strategic objectives. Draft reports were refined through plenary discussions and finalized by consensus during dedicated SIGENP meetings. Across all areas, shared priorities emerged: advancing precision and personalized medicine, integrating multi‐omics and digital tools, and promoting pediatric‐specific evidence through multicenter collaboration and harmonized registries. Disease‐specific gaps include early diagnosis and biomarker discovery in IBD and liver disease, standardization of pediatric endoscopy and motility diagnostics, optimization of nutritional interventions and intestinal failure management, and the exploration of organoid and immune models in celiac disease and food allergy. This review outlines a comprehensive research agenda in pediatric gastroenterology, hepatology, and nutrition developed through a structured SIGENP expert process. It provides a strategic framework to guide future research initiatives, foster collaboration, and ultimately improve outcomes for children with gastrointestinal and nutritional disorders.

JPGN Reports
Università Cattolica del Sacro Cuore (IT), University of Messina (IT), University of Insubria (IT), University of Verona (IT), Marche Polytechnic University (IT), Boston Children's Hospital (US), University of Udine (IT), University of Salerno (IT), University of Milan (IT), University of Campania "Luigi Vanvitelli" (IT), IRCCS Materno Infantile Burlo Garofolo (IT), Great Ormond Street Hospital (GB), Casa Sollievo della Sofferenza (IT), Ospedale Filippo Del Ponte Varese (IT), Istituto Giannina Gaslini (IT), Agostino Gemelli University Polyclinic (IT), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Magna Graecia University (IT), Ospedale Maggiore Carlo Alberto Pizzardi (IT), European Centre for Theoretical Studies in Nuclear Physics and Related Areas (IT), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), Ospedale Papa Giovanni XXIII (IT), Meyer Children's Hospital (IT), Federico II University Hospital (IT), Bambino Gesù Children's Hospital (IT), Santobono Children's Hospital (IT), Ospedale dei Bambini Vittore Buzzi (IT), Ospedale Pediatrico Giovanni XXIII (IT), Ospedale San Donato (IT), Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT), University College London (GB), Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT), University of Bari Aldo Moro (IT), University of Naples Federico II (IT), University of Brescia (IT), Sapienza University of Rome (IT), University of Palermo (IT)
Openalex Percentile: Top 9%
Celiac Disease Research and Management
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