Temperament as a Risk Factor for Clinical Diagnosis During the Transition From Childhood Through Adolescence and Young Adulthood: A 16-Year Multimethod Longitudinal Study

Identifying early temperamental predictors of later psychopathology is crucial for detecting at-risk individuals and implementing targeted prevention efforts. However, there is limited research using laboratory-based observations of temperament and “gold-standard” assessments of psychiatric disorders across early adolescence and young adulthood. Using a multimethod, prospective longitudinal study ( N = 291), we investigated whether temperament (i.e., behavioral inhibition [BI], exuberance) observed at 24 and 36 months predicted the likelihood of psychiatric disorders across adolescence/young adulthood. Results suggested that early childhood BI was not predictive of anxiety diagnosis over time; however, exuberance predicted attention-deficit/hyperactivity disorder at ages 12, 15, and 18 years. Results add to prior work that has rarely found direct relations between early temperament and psychopathology and highlight early adolescence/young adulthood as a vulnerable time for the development of psychopathology.

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Publication Details

Journal
Clinical Psychological Science
Published
2026-08-25
DOI
https://doi.org/10.1177/21677026251315150
Primary Topic
Child and Adolescent Psychosocial and Emotional Development
Type
article
Field-Weighted Citation Impact
0.00

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article

Temperament as a Risk Factor for Clinical Diagnosis During the Transition From Childhood Through Adolescence and Young Adulthood: A 16-Year Multimethod Longitudinal Study

Nicole E. Lorenzo, Selin Zeytinoglu, Hong N.T. Bui, Nathan A. Fox et al.
Clinical Psychological Science
Child and Adolescent Psychosocial and Emotional Development
article

Temperament as a Risk Factor for Clinical Diagnosis During the Transition From Childhood Through Adolescence and Young Adulthood: A 16-Year Multimethod Longitudinal Study

Nicole E. Lorenzo, Selin Zeytinoglu, Hong N.T. Bui, Nathan A. Fox, Daniel S. Pine, Heather Henderson, Andrea Chronis-Tuscano, Kathyrn A. Degnan
article en

Abstract

Identifying early temperamental predictors of later psychopathology is crucial for detecting at-risk individuals and implementing targeted prevention efforts. However, there is limited research using laboratory-based observations of temperament and “gold-standard” assessments of psychiatric disorders across early adolescence and young adulthood. Using a multimethod, prospective longitudinal study ( N = 291), we investigated whether temperament (i.e., behavioral inhibition [BI], exuberance) observed at 24 and 36 months predicted the likelihood of psychiatric disorders across adolescence/young adulthood. Results suggested that early childhood BI was not predictive of anxiety diagnosis over time; however, exuberance predicted attention-deficit/hyperactivity disorder at ages 12, 15, and 18 years. Results add to prior work that has rarely found direct relations between early temperament and psychopathology and highlight early adolescence/young adulthood as a vulnerable time for the development of psychopathology.

Clinical Psychological Science
National Institutes of Health (US), University of Waterloo (CA), American University (US), University of Maryland, College Park (US), Catholic University of America (US)
National Institutes of Health, National Institute of Mental Health
Openalex Percentile: Top 7%
Child and Adolescent Psychosocial and Emotional Development
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Temperament as a Risk Factor for Clinical Diagnosis During the Transition From Childhood Through Adolescence and Young Adulthood: A 16-Year Multimethod Longitudinal Study — Nicole E. Lorenzo, Selin Zeytinoglu, et al. · Clinical Psychological Science (2026) | TGRS Research Map | TGRS