In vitro activity of aztreonam-avibactam against carbapenem-resistant Pseudomonas aeruginosa from Southern Brazil
Abstract Carbapenem-resistant Pseudomonas aeruginosa (CR-PA) has limited therapeutic options, particularly when metallo-β-lactamases are present. We evaluated aztreonam-avibactam (AZA) against 48 clinical P. aeruginosa isolates, including 44 CR-PA with 18 difficult-to-treat resistant isolates. Class B carbapenemase genes were present in 50.0%, mainly bla NDM−1 . AZA MICs ranged from ≤ 0.5 to > 256 µg/mL (MIC50/90, 16/64 µg/mL), and 58.3% of isolates had AZA MICs ≤ 16 µg/mL. Among aztreonam-resistant isolates, AZA restored susceptibility in 33.3%, less frequently than aztreonam plus ceftazidime-avibactam (63.0%).
Authors
- Juliana Caierão (ORCID: https://orcid.org/0000-0002-8776-8447)
- Patricia Orlandi Barth (ORCID: https://orcid.org/0000-0003-0763-1430)
- Afonso Luís Barth (ORCID: https://orcid.org/0000-0002-7969-3908)
- Gabriela da Silva Collar (ORCID: https://orcid.org/0000-0003-2819-0769)
- Natália Kehl Moreira (ORCID: https://orcid.org/0000-0002-1060-6482)
- Maria do Carmo Fontourac Pereira
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital Nossa Senhora da Conceição (BR)
- Grupo Hospitalar Conceição (BR)
Publication Details
- Journal
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2026-08-26
- DOI
- https://doi.org/10.1007/s10096-026-05647-6
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto Nacional de Pesquisas em Resistência a Antimicrobianos
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Hospital de Clínicas de Porto Alegre
- Universidade Federal do Rio Grande do Sul
- Fundação Instituto de Pesquisas Econômicas