Reported Changes in Glycated Hemoglobin and Blood Pressure Across Common Diabetes Interventions: An Exploratory Secondary Analysis

This exploratory secondary analysis compares reported changes in glycated hemoglobin (HbA1c), blood pressure, and insulin-related outcomes across ten pharmacological and lifestyle interventions for diabetes. Treatment-effect estimates were compiled from previously published scientific and medical sources and organized into a standardized modeling framework. During reconstruction of the original project, two demonstrable calculation errors were corrected without altering any source-derived treatment-effect values. Exploratory one-way ANOVA of the corrected modeled dataset produced F(11,24) = 2.68, p = .021 for HbA1c and F(11,24) = 1.72, p = .128 for blood pressure. Because the dataset consists of literature-derived and modeled values rather than independent patient-level observations, these statistics should not be interpreted as evidence of comparative clinical efficacy. This Zenodo record contains the reconstructed research manuscript, a cleaned publication data workbook with a correction log and source-attribution audit, and the unchanged original research poster. The original poster is preserved as a historical project output; where calculations or interpretations differ, the reconstructed manuscript and cleaned dataset provide the corrected analysis.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-08-25
DOI
https://doi.org/10.5281/zenodo.22100501
Primary Topic
Diabetes, Cardiovascular Risks, and Lipoproteins
Type
preprint
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preprint

Reported Changes in Glycated Hemoglobin and Blood Pressure Across Common Diabetes Interventions: An Exploratory Secondary Analysis

Siddarth Shakthimani
Zenodo (CERN European Organization for Nuclear Research)
Diabetes, Cardiovascular Risks, and Lipoproteins
preprint

Reported Changes in Glycated Hemoglobin and Blood Pressure Across Common Diabetes Interventions: An Exploratory Secondary Analysis

Siddarth Shakthimani
preprint en

Abstract

This exploratory secondary analysis compares reported changes in glycated hemoglobin (HbA1c), blood pressure, and insulin-related outcomes across ten pharmacological and lifestyle interventions for diabetes. Treatment-effect estimates were compiled from previously published scientific and medical sources and organized into a standardized modeling framework. During reconstruction of the original project, two demonstrable calculation errors were corrected without altering any source-derived treatment-effect values. Exploratory one-way ANOVA of the corrected modeled dataset produced F(11,24) = 2.68, p = .021 for HbA1c and F(11,24) = 1.72, p = .128 for blood pressure. Because the dataset consists of literature-derived and modeled values rather than independent patient-level observations, these statistics should not be interpreted as evidence of comparative clinical efficacy. This Zenodo record contains the reconstructed research manuscript, a cleaned publication data workbook with a correction log and source-attribution audit, and the unchanged original research poster. The original poster is preserved as a historical project output; where calculations or interpretations differ, the reconstructed manuscript and cleaned dataset provide the corrected analysis.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Diabetes, Cardiovascular Risks, and Lipoproteins
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