Exponential stabilization of spatiotemporal discrete stochastic gene regulatory networks via Weyl almost-periodic analysis and feedback control

This paper studies the dynamics and control of spatiotemporal discrete stochastic gene regulatory networks with diffusion, time delays, and Brownian perturbations. A unified discrete model is constructed by combining exponential Euler, central finite difference, and Euler–Maruyama schemes. To describe recurrent stochastic gene-expression patterns, mean-square Weyl almost periodic sequences are introduced. Under suitable Lipschitz-type assumptions, the existence and uniqueness of such solutions are established using Leray–Schauder degree theory and discrete Gronwall inequalities. An exponential-type feedback controller is further designed to ensure global exponential mean-square stabilization toward the almost-periodic trajectory. The results provide a theoretical basis for analyzing and controlling stochastic spatiotemporal gene networks and can be extended to broader diffusion-driven stochastic complex systems.

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Publication Details

Journal
Proceedings of the Institution of Mechanical Engineers Part I Journal of Systems and Control Engineering
Published
2026-08-25
DOI
https://doi.org/10.1177/09596518261474274
Primary Topic
Gene Regulatory Network Analysis
Type
article
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article

Exponential stabilization of spatiotemporal discrete stochastic gene regulatory networks via Weyl almost-periodic analysis and feedback control

Shaobin Rao, Yuntao Liu
Proceedings of the Institution of Mechanical Engineers Part I Journal of Systems and Control Engineering
Gene Regulatory Network Analysis
article

Exponential stabilization of spatiotemporal discrete stochastic gene regulatory networks via Weyl almost-periodic analysis and feedback control

Shaobin Rao, Yuntao Liu
article en

Abstract

This paper studies the dynamics and control of spatiotemporal discrete stochastic gene regulatory networks with diffusion, time delays, and Brownian perturbations. A unified discrete model is constructed by combining exponential Euler, central finite difference, and Euler–Maruyama schemes. To describe recurrent stochastic gene-expression patterns, mean-square Weyl almost periodic sequences are introduced. Under suitable Lipschitz-type assumptions, the existence and uniqueness of such solutions are established using Leray–Schauder degree theory and discrete Gronwall inequalities. An exponential-type feedback controller is further designed to ensure global exponential mean-square stabilization toward the almost-periodic trajectory. The results provide a theoretical basis for analyzing and controlling stochastic spatiotemporal gene networks and can be extended to broader diffusion-driven stochastic complex systems.

Proceedings of the Institution of Mechanical Engineers Part I Journal of Systems and Control Engineering
Kunming University of Science and Technology (CN), Soochow University (CN)
Openalex Percentile: Top 17%
Gene Regulatory Network Analysis
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Exponential stabilization of spatiotemporal discrete stochastic gene regulatory networks via Weyl almost-periodic analysis and feedback control — Shaobin Rao, Yuntao Liu · Proceedings of the Institution of Mechanical Engineers Part I Journal of Systems and Control Engineering (2026) | TGRS Research Map | TGRS