CACA Guidelines for holistic integrative assessment (2025)
Abstract The complexity and heterogeneity of malignant tumors necessitate a paradigm shift from a disease-centric to a patient-centric model of care. Cancer holistic integrative assessment (CHIA) is a multidimensional evaluation process that forms the cornerstone of personalized oncology. CHIA is characterized by four core principles: integrative philosophy, multidimensionality, dynamic individualization, and multidisciplinary collaboration. Key assessment domains include: 1) General status (performance status, physical function, nutrition); 2) Symptom burden ( pain, fatigue, et al.); 3) Organ function and comorbidities to gauge treatment tolerance; 4) Psychological and cognitive state (distress, anxiety, depression, cognitive function); 5) Family and social support systems, including financial toxicity; 6) Tumor biology (stage, molecular profile) to define therapeutic goals; and 7) Genetic risk 8)fertility preservation needs 9) Traditional Chinese Medicine Tumor Pathogenesis Identification and Evaluation. CHIA is a pivotal, dynamic process essential for tailoring safe, effective, and humanistic anticancer therapy. Its systematic implementation, supported by training, standardized protocols, and digital tools, is fundamental to advancing precision oncology and achieving the strategic goal of "Healthy China."
Authors
- Lei Ni (ORCID: https://orcid.org/0000-0002-2632-3647)
- Guibin Qiao
- Rongbo Lin (ORCID: https://orcid.org/0000-0002-6877-1691)
- Jin Zheng (ORCID: https://orcid.org/0000-0001-6219-0864)
- Jizong Jiang (ORCID: https://orcid.org/0000-0002-1604-1101)
- Jinghui Bai
- Minghua Cong
- Yi He (ORCID: https://orcid.org/0000-0002-9503-0565)
- Hongmei Zhang (ORCID: https://orcid.org/0000-0003-4722-2180)
- Bo Liu (ORCID: https://orcid.org/0009-0003-8775-1244)
- Jie Min (ORCID: https://orcid.org/0000-0001-7073-1229)
- Qian Chu (ORCID: https://orcid.org/0000-0001-8192-7630)
- Yong Liu (ORCID: https://orcid.org/0009-0004-0062-3395)
- Duanqi Liu
- Zhi Guo
- Hongyan Zhang
- Qian Li
- Xiaomei Li
- Feng Liang
- Xiaowen Wang
- Hongxia Li
- Beibei Chen
- Xiaobing Chen
- Qiuling Shi
- Fei Wang
- Wenli Zhou
- Min Li
Institutions
- Central South University (CN)
- Shanxi Medical University (CN)
- Xuzhou Medical College (CN)
- Shenzhen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Peking University Cancer Hospital (CN)
- Zhujiang Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Chinese Medical Center (US)
- Henan Cancer Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
- Xijing Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Tongji Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- Liaoning Cancer Hospital & Institute (CN)
- Shandong First Medical University (CN)
- Anshan Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
- Chongqing Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Holistic Integrative Oncology
- Published
- 2026-08-24
- DOI
- https://doi.org/10.1007/s44178-026-00277-6
- Primary Topic
- Economic and Financial Impacts of Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00