N6-methyladenosine (m6A) RNA modification in muscle stem cells and skeletal muscle regeneration

N 6 -methyladenosine (m 6 A) is a highly conserved posttranscriptional modification essential for gene expression, cellular function, and the determination of stem cell fates. As a result, it is regulated by a variety of mechanisms and remains a promising field of study. m 6 A RNA methylation is mediated by multiple classes of proteins, known as writers, erasers, and readers, which are in turn controlled by various transcription factors and regulatory pathways. Dysregulation of these fundamental processes is implicated in a wide range of diseases and disorders, exemplifying their importance in guiding normal physiological activity. In this review, we focused on the effects of m 6 A modification on muscle stem cells (MuSCs), also known as satellite cells, a critical component of skeletal muscle development and regeneration. Further, we evaluated the contemporary literature and expert perspectives to outline the mechanisms of m 6 A RNA methylation, emphasizing their roles in MuSCs and their potential for developing novel therapeutic strategies.