Use of a Retinal Phantom to Facilitate Adaptive Optics Scanning Light Ophthalmoscopy Imaging in a Multicenter Clinical Trial

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Publication Details

Journal
Translational Vision Science & Technology
Published
2026-08-24
DOI
https://doi.org/10.1167/tvst.15.8.20
Primary Topic
Ophthalmology and Visual Impairment Studies
Type
article
Field-Weighted Citation Impact
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article

Use of a Retinal Phantom to Facilitate Adaptive Optics Scanning Light Ophthalmoscopy Imaging in a Multicenter Clinical Trial

Jessica Wong, Kaitlyn Sapoznik, Raymond L. Warner, Alexander Schill et al.
Translational Vision Science & Technology
Ophthalmology and Visual Impairment Studies
article

Use of a Retinal Phantom to Facilitate Adaptive Optics Scanning Light Ophthalmoscopy Imaging in a Multicenter Clinical Trial

Jessica Wong, Kaitlyn Sapoznik, Raymond L. Warner, Alexander Schill, Peiluo Xu, Anant Agrawal, Nivedhitha Govindasamy, Joseph Kreis, Jessica I. W. Morgan, Emma Warr, Robert F. Cooper, Palash Bharadwaj, Jacque L. Duncan, Mina Gaffney, Jeremy D. Rogers, Daniel X. Hammer, Ramkumar Sabesan, Benjamin Wendel, Yushan Yang, Sergey Tarima, Angelos Kalitzeos, Joseph Carroll, Niamh Wynne, Brian P. Higgins, Jason Porter, Yu You Jiang, Yiyi Wang, Ryan D. Sochol, Amy L. Green, Michel Michaelides, Ian Rosenthal
article en

Abstract

Purpose: To describe the use of a model eye-mounted retinal phantom to support adaptive optics scanning light ophthalmoscope (AOSLO) imaging in a multicenter clinical trial (NCT05537220). Methods: Six three-dimensional-printed retinal phantoms were mounted in model eyes. These phantoms contain equally spaced arrays of reflective "cone-like" structures mimicking foveal cone photoreceptor spacing. Intrasession repeatability of phantom imaging was assessed for all six phantoms on two custom AOSLOs. One phantom was also imaged on two additional AOSLOs to assess interdevice reproducibility. Lastly, each of the six phantoms was imaged longitudinally at their respective trial sites. Results: Intrasession repeatability of phantom-derived horizontal "cone" spacing measures was high for two different AOSLOs. However, intersystem differences were found in the average horizontal "cone" spacing of five of eight patches assessed. Across four unique AOSLOs, intersystem differences were found in the average horizontal "cone" spacing of seven of eight patches assessed. A linear regression analysis of longitudinal phantom imaging with a single AOSLO revealed few significant changes in horizontal "cone" spacing over the course of about 2 years. Similar results were observed for vertical "cone" spacing measures across the three experiments. Conclusions: Longitudinal spacing measurements were generally stable in our study. However, small but significant differences in spacing were observed between systems. The approach described here may facilitate combining cone metrics extracted from images acquired using different AOSLOs in multicenter studies. Translational Relevance: Cross-system validation strategies can support the use of AOSLO imaging in multicenter clinical trials.

Translational Vision Science & TechnologyVol. 15(8)
Marquette University (US), McPherson College (US), United States Food and Drug Administration (US), Moorfields Eye Hospital NHS Foundation Trust (GB), Center for Devices and Radiological Health (US), University of Wisconsin–Madison (US), University of Kentucky (US), Penn Presbyterian Medical Center (US), University of California, San Francisco (US), Marshall B. Ketchum University (US), University of Washington (US), Medical College of Wisconsin (US), Office of Science (US), The Retina Center (US), Moorfields Eye Hospital (GB), University of Houston (US), University College London (GB), Smith-Kettlewell Eye Research Institute (US), University of Maryland, College Park (US), University of Pennsylvania (US)
Openalex Percentile: Top 9%
Ophthalmology and Visual Impairment Studies
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