Use of a Retinal Phantom to Facilitate Adaptive Optics Scanning Light Ophthalmoscopy Imaging in a Multicenter Clinical Trial
{"Purpose:":[0],"To":[1],"describe":[2],"the":[3,82,114,134,166,182,232],"use":[4,233],"of":[5,42,53,81,96,119,121,139,141,149,168,234],"a":[6,21,154],"model":[7,34],"eye-mounted":[8],"retinal":[9,29],"phantom":[10,54,67,151],"to":[11,75],"support":[12,231],"adaptive":[13],"optics":[14],"scanning":[15],"light":[16],"ophthalmoscope":[17],"(AOSLO)":[18],"imaging":[19,55,152,236],"in":[20,33,113,133,161,192,200,222,237],"multicenter":[22,223,238],"clinical":[23,239],"trial":[24,91],"(NCT05537220).":[25],"Methods:":[26],"Six":[27],"three-dimensional-printed":[28],"phantoms":[30,37,61,84],"were":[31,111,131,174,189,202],"mounted":[32],"eyes.":[35],"These":[36],"contain":[38],"equally":[39],"spaced":[40],"arrays":[41],"reflective":[43],"\\"cone-like\\"":[44],"structures":[45],"mimicking":[46],"foveal":[47],"cone":[48,213],"photoreceptor":[49],"spacing.":[50],"Intrasession":[51,94],"repeatability":[52,95],"was":[56,68,85,102],"assessed":[57],"for":[58,104,176],"all":[59],"six":[60,83],"on":[62,71],"two":[63,72,105],"custom":[64],"AOSLOs.":[65,107],"One":[66],"also":[69],"imaged":[70,86],"additional":[73],"AOSLOs":[74,221],"assess":[76],"interdevice":[77],"reproducibility.":[78],"Lastly,":[79],"each":[80],"longitudinally":[87],"at":[88],"their":[89],"respective":[90],"sites.":[92],"Results:":[93],"phantom-derived":[97],"horizontal":[98,116,136,162],"\\"cone\\"":[99,117,137,163,178],"spacing":[100,118,138,164,179,187,201],"measures":[101,180],"high":[103],"different":[106,220],"However,":[108,195],"intersystem":[109,129],"differences":[110,130,199],"found":[112,132],"average":[115,135],"five":[120],"eight":[122,142],"patches":[123,143],"assessed.":[124,144],"Across":[125],"four":[126],"unique":[127],"AOSLOs,":[128],"seven":[140],"A":[145],"linear":[146],"regression":[147],"analysis":[148],"longitudinal":[150],"with":[153],"single":[155],"AOSLO":[156,235],"revealed":[157],"few":[158],"significant":[159,198],"changes":[160],"over":[165],"course":[167],"about":[169],"2":[170],"years.":[171],"Similar":[172],"results":[173],"observed":[175,203],"vertical":[177],"across":[181],"three":[183],"experiments.":[184],"Conclusions:":[185],"Longitudinal":[186],"measurements":[188],"generally":[190],"stable":[191],"our":[193],"study.":[194],"small":[196],"but":[197],"between":[204],"systems.":[205],"The":[206],"approach":[207],"described":[208],"here":[209],"may":[210],"facilitate":[211],"combining":[212],"metrics":[214],"extracted":[215],"from":[216],"images":[217],"acquired":[218],"using":[219],"studies.":[224],"Translational":[225],"Relevance:":[226],"Cross-system":[227],"validation":[228],"strategies":[229],"can":[230],"trials.":[240]}
Authors
- Jessica Wong
- Kaitlyn Sapoznik
- Raymond L. Warner (ORCID: https://orcid.org/0000-0003-0704-8333)
- Alexander Schill
- Peiluo Xu
- Anant Agrawal (ORCID: https://orcid.org/0000-0001-8573-0042)
- Nivedhitha Govindasamy (ORCID: https://orcid.org/0009-0008-2913-9790)
- Joseph Kreis (ORCID: https://orcid.org/0000-0003-4620-2364)
- Jessica I. W. Morgan (ORCID: https://orcid.org/0000-0002-9878-7336)
- Emma Warr
- Robert F. Cooper (ORCID: https://orcid.org/0000-0002-0796-1387)
- Palash Bharadwaj (ORCID: https://orcid.org/0000-0003-0722-6697)
- Jacque L. Duncan (ORCID: https://orcid.org/0000-0002-9593-6412)
- Mina Gaffney (ORCID: https://orcid.org/0000-0001-5076-3354)
- Jeremy D. Rogers (ORCID: https://orcid.org/0000-0003-3049-2803)
- Daniel X. Hammer (ORCID: https://orcid.org/0000-0003-0532-1914)
- Ramkumar Sabesan (ORCID: https://orcid.org/0000-0003-0895-7037)
- Benjamin Wendel
- Yushan Yang (ORCID: https://orcid.org/0009-0009-6185-6957)
- Sergey Tarima
- Angelos Kalitzeos (ORCID: https://orcid.org/0000-0001-8345-0557)
- Joseph Carroll
- Niamh Wynne
- Brian P. Higgins
- Jason Porter
- Yu You Jiang
- Yiyi Wang
- Ryan D. Sochol
- Amy L. Green
- Michel Michaelides
- Ian Rosenthal
Institutions
- Marquette University (US)
- McPherson College (US)
- United States Food and Drug Administration (US)
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- Center for Devices and Radiological Health (US)
- University of Wisconsin–Madison (US)
- University of Kentucky (US)
- Penn Presbyterian Medical Center (US)
- University of California, San Francisco (US)
- Marshall B. Ketchum University (US)
- University of Washington (US)
- Medical College of Wisconsin (US)
- Office of Science (US)
- The Retina Center (US)
- Moorfields Eye Hospital (GB)
- University of Houston (US)
- University College London (GB)
- Smith-Kettlewell Eye Research Institute (US)
- University of Maryland, College Park (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Translational Vision Science & Technology
- Published
- 2026-08-24
- DOI
- https://doi.org/10.1167/tvst.15.8.20
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00