V1-dominant Recurrence of Trigeminal Neuralgia after Gamma Knife Radiosurgery for V2–V3 Pain in a Patient with Persistent Vertebral Artery Compression: A Case Report

Gamma knife radiosurgery is an established minimally-invasive treatment for trigeminal neuralgia, but recurrence remains a concern, and the trigeminal division involved at relapse is rarely documented. A 63-year-old man developed recurrent trigeminal neuralgia 3 years after gamma knife radiosurgery for left V2–V3 pain, presenting this time with isolated V1 involvement. Magnetic resonance imaging revealed persistent, severe neurovascular compression of the left trigeminal root by a tortuous left vertebral artery with marked nerve flattening. Microvascular decompression achieved immediate and complete pain relief, and postoperative imaging confirmed full decompression. This case illustrates a V1-dominant recurrence pattern after gamma knife radiosurgery in the setting of persistent, deforming neurovascular compression by a tortuous vertebral artery. Although division-specific radiosurgical effects could not be confirmed, the complete resolution of pain after microvascular decompression supports the clinical importance of reassessing persistent mechanical compression when recurrent pain appears in a different trigeminal division.

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Publication Details

Journal
NMC Case Report Journal
Published
2026-08-24
DOI
https://doi.org/10.2176/jns-nmc.2026-0082
Primary Topic
Trigeminal Neuralgia and Treatments
Type
article
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article

V1-dominant Recurrence of Trigeminal Neuralgia after Gamma Knife Radiosurgery for V2–V3 Pain in a Patient with Persistent Vertebral Artery Compression: A Case Report

Hiroaki Minami, Yumiko Okada, Akihiro Okada, Yasunori YOSHIDA et al.
NMC Case Report Journal
Trigeminal Neuralgia and Treatments
article

V1-dominant Recurrence of Trigeminal Neuralgia after Gamma Knife Radiosurgery for V2–V3 Pain in a Patient with Persistent Vertebral Artery Compression: A Case Report

Hiroaki Minami, Yumiko Okada, Akihiro Okada, Yasunori YOSHIDA, Hiroaki MATSUMOTO, Yasuhisa YOSHIDA
article en

Abstract

Gamma knife radiosurgery is an established minimally-invasive treatment for trigeminal neuralgia, but recurrence remains a concern, and the trigeminal division involved at relapse is rarely documented. A 63-year-old man developed recurrent trigeminal neuralgia 3 years after gamma knife radiosurgery for left V2–V3 pain, presenting this time with isolated V1 involvement. Magnetic resonance imaging revealed persistent, severe neurovascular compression of the left trigeminal root by a tortuous left vertebral artery with marked nerve flattening. Microvascular decompression achieved immediate and complete pain relief, and postoperative imaging confirmed full decompression. This case illustrates a V1-dominant recurrence pattern after gamma knife radiosurgery in the setting of persistent, deforming neurovascular compression by a tortuous vertebral artery. Although division-specific radiosurgical effects could not be confirmed, the complete resolution of pain after microvascular decompression supports the clinical importance of reassessing persistent mechanical compression when recurrent pain appears in a different trigeminal division.

NMC Case Report JournalVol. 13(0)
Osaka City General Hospital (JP), Nishida Hospital (JP)
Openalex Percentile: Top 11%
Trigeminal Neuralgia and Treatments
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V1-dominant Recurrence of Trigeminal Neuralgia after Gamma Knife Radiosurgery for V2–V3 Pain in a Patient with Persistent Vertebral Artery Compression: A Case Report — Hiroaki Minami, Yumiko Okada, et al. · NMC Case Report Journal (2026) | TGRS Research Map | TGRS