Triazole-based hybrid molecules in anticancer drug discovery: structural classes and mechanistic insights, 2014–2025

Triazole-based hybrids have evolved into important pharmacophores in the search for anticancer drugs because of their varied biological profiles and structural adaptability. The versatility of triazole scaffolds in forming hybrid molecules with other compounds such as pyridines, coumarins, chalcones, pyrimidines, indoles, etc., has expanded the range of potential anticancer compounds. This review presents an overview of recent progress in the biological assessment of triazole-based hybrid compounds as potential anticancer agents, focusing on their structure, activity, and mechanisms of action. The findings outlined here underscore the therapeutic potential of triazole hybrids and lay the groundwork for designing future anticancer drug candidates.