Adjunct Low-Intensity Extracorporeal Shockwave Therapy (LiESWT) for Acute and Chronic Epididymitis: A Case Series of 11 Patients.

Acute and chronic epididymitis frequently presents with significant morbidity due to severe pain and inflammation. Standard management includes antibiotics and analgesics, yet persistent symptoms and complications often occur, sometimes leading to orchiectomy. Low-intensity extracorporeal shockwave therapy (LiESWT), proven effective in reducing inflammation and promoting tissue repair in various urological conditions, was evaluated as an adjunct treatment for epididymitis. Eleven men with ultrasound-confirmed acute or chronic epididymitis were treated with adjunct Li-ESWT in addition to guideline-based antibiotic therapy. All patients demonstrated rapid improvement of symptoms, including significant pain reduction and normalization of inflammatory markers, with no adverse events observed. LiESWT was well-tolerated, and analgesic requirements appeared reduced compared with typical clinical courses. Initial clinical experience suggests that LiESWT may represent a promising, safe, and effective adjunct treatment option for acute and chronic epididymitis, with the potential to enhance recovery and reduce symptom burden. A randomized, multicenter trial is planned to further evaluate its efficacy.