Human biomarker navigator

Abstract Biomarkers play a pivotal role in contemporary medical research, particularly in the early diagnosis of diseases and personalized treatment. Although previous studies have systematically reviewed markers across various disease domains, an integrated framework that connects major physiological systems, encompasses multiple organs, and spans a broad spectrum of diseases is still lacking. In the context of modern health challenges, marked by the high prevalence of chronic diseases and widespread comorbidities, establishing a panoramic biomarker navigation system is imperative. This review offers the initial comprehensive elucidation of the biomarker interaction networks across diverse systems, organs, and diseases, and delineates the operational framework for establishing a “biomarker navigation system”. The core contribution of this work is a transition from ‘knowledge enumeration’ to a more integrated, systems‐level approach. This provides new perspectives in systems biology for understanding the shared pathological foundations of comorbidities. Furthermore, it provides a theoretical basis for a reorientation in medicine, from a focus on ‘treating existing diseases’ to ‘preventive interventions’ and from ‘single‐disease management’ to a comprehensive, systems‐based approach. To facilitate the exploration and application of this system–organ–disease–biomarker network, we developed the “Human Biomarker Navigator” web platform ( http://www.hbiomarker.com ), which allows researchers and clinicians to efficiently retrieve the functional characteristics and clinical significance of diverse biomarkers across different disease contexts.

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Publication Details

Journal
iMeta
Published
2026-08-20
DOI
https://doi.org/10.1002/imt2.70157
Primary Topic
Bioinformatics and Genomic Networks
Type
article
Field-Weighted Citation Impact
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article

Human biomarker navigator

Bendong Yang, Jingda Li, Lingru Li, Wenjun Mao et al.
iMeta
Bioinformatics and Genomic Networks
article

Human biomarker navigator

Bendong Yang, Jingda Li, Lingru Li, Wenjun Mao, Yuan Wan, Yanfei Zheng, Lvyun Zhu, Tianhuan Peng, Zeping Gui, Chenghu Song, Wenlong Sun, Yang Luo, Xiaohui Fan, Tong Shao, Mengyao Li, Jing Liu, Gökhan Zengin, Qingqing Han, Zijie Wang, Qian Zhang, Jun Luo, Zukang Chang, Pingping Guo, Gangao Yang, Xueying Zhang, Jun Li, Quan Yuan, Maojun Jiang, Tariq Saeed, Jinghan Jia
article en

Abstract

Abstract Biomarkers play a pivotal role in contemporary medical research, particularly in the early diagnosis of diseases and personalized treatment. Although previous studies have systematically reviewed markers across various disease domains, an integrated framework that connects major physiological systems, encompasses multiple organs, and spans a broad spectrum of diseases is still lacking. In the context of modern health challenges, marked by the high prevalence of chronic diseases and widespread comorbidities, establishing a panoramic biomarker navigation system is imperative. This review offers the initial comprehensive elucidation of the biomarker interaction networks across diverse systems, organs, and diseases, and delineates the operational framework for establishing a “biomarker navigation system”. The core contribution of this work is a transition from ‘knowledge enumeration’ to a more integrated, systems‐level approach. This provides new perspectives in systems biology for understanding the shared pathological foundations of comorbidities. Furthermore, it provides a theoretical basis for a reorientation in medicine, from a focus on ‘treating existing diseases’ to ‘preventive interventions’ and from ‘single‐disease management’ to a comprehensive, systems‐based approach. To facilitate the exploration and application of this system–organ–disease–biomarker network, we developed the “Human Biomarker Navigator” web platform ( http://www.hbiomarker.com ), which allows researchers and clinicians to efficiently retrieve the functional characteristics and clinical significance of diverse biomarkers across different disease contexts.

iMeta
Zhejiang Chinese Medical University (CN), Shandong University of Technology (CN), International Islamic University, Islamabad (PK), Binghamton University (US), Selçuk University (TR), Hunan University (CN), National University of Defense Technology (CN), Beijing University of Chinese Medicine (CN), Yangtze University (CN), Renji Hospital (CN), Wuhan University (CN), Zhejiang Modern Chinese Medicine and Natural Medicine Research Institute (China) (CN), Chongqing Emergency Medical Center (CN), Second Affiliated Hospital of Nanjing Medical University (CN), Wuxi People's Hospital (CN), Shandong First Medical University (CN), Inner Mongolia Medical University (CN), Nanjing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 16%
Bioinformatics and Genomic Networks
DOIOpen Access PDFOpenAlex
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