Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech
This review highlights key advances in chemical biology reported in 2025, curated by students in the Advanced Chemical Biology course (Ch/Bi145) at the California Institute of Technology (Caltech). The selected studies span advances in bioconjugation and bioorthogonal chemistry, visualization and sensing, interaction profiling, precision control of biological systems, emerging therapeutic modalities, and synthetic chemical biology. Together, they illustrate how innovative molecular design continues to expand our ability to interrogate and manipulate biological systems.
Authors
- Iuliia D. Kuleshova (ORCID: https://orcid.org/0009-0006-4384-3907)
- Yihan Lin (ORCID: https://orcid.org/0000-0002-2763-5538)
- Gabriel P. Ashton-Rickardt
- Esther Leem (ORCID: https://orcid.org/0009-0001-2512-1381)
- Omar Salah (ORCID: https://orcid.org/0000-0003-4888-3933)
- Emily G. Nikas (ORCID: https://orcid.org/0000-0003-0455-605X)
- Johannes Morstein (ORCID: https://orcid.org/0000-0002-6940-288X)
- Chloe S. Cerione
- Jonathan Farhi (ORCID: https://orcid.org/0000-0001-8720-496X)
- Carlynda Lee (ORCID: https://orcid.org/0000-0002-3845-1793)
- Leo Qi
- Nikaya Polsani (ORCID: https://orcid.org/0000-0001-5343-4759)
- Victoria Nisoli
- Jade K. Konsler
- Haiyun Liu (ORCID: https://orcid.org/0000-0002-0485-2695)
- Yiyang Zhang (ORCID: https://orcid.org/0000-0002-7201-1281)
- Dong Kyu Chung
- Lun-Hsin Kuo (ORCID: https://orcid.org/0009-0008-3181-8493)
- Albert Qiang
- Zachary B. Green (ORCID: https://orcid.org/0000-0002-1367-6689)
- Jingkai Hou
- Aline Milach Teixeira
- Ethan N. Lin (ORCID: https://orcid.org/0009-0005-0023-5525)
- Naiara Lebron Acosta
- Madelyn S. Gilbert
- Erica R. Hengartner (ORCID: https://orcid.org/0009-0008-0294-0246)
- Qinge Liu
- Sebastian P. Rohrer (ORCID: https://orcid.org/0000-0003-0107-088X)
- Yanlin Liu (ORCID: https://orcid.org/0009-0004-5028-6809)
- Sean A. Corman (ORCID: https://orcid.org/0009-0000-5254-1122)
- Raphael Ren‐Yian Shu
- Caroline S. Smith (ORCID: https://orcid.org/0009-0005-0702-9812)
- Dayeon Kang
- Camilla M. Power
Institutions
- California Institute of Technology (US)
Publication Details
- Journal
- ChemBioChem
- Published
- 2026-08-21
- DOI
- https://doi.org/10.1002/cbic.70485
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00