Antiphospholipid Antibody Syndrome Presenting as Multiple Finger Gangrene: Diagnostic Dilemmas and Therapeutic Challenges: A Case Report

Abstract Antiphospholipid antibody syndrome (APS), also called Hughes Syndrome or “Sticky Blood Syndrome,” is an acquired autoimmune disorder, where the patient develops antibodies against membrane anionic phospholipids that present as a hypercoagulable state with arterial and venous thrombosis and repeated miscarriages, heart attack, and stroke. It can be either Primary, when antiphospholipid antibodies are detected alone, or secondary in association with other rheumatic or autoimmune diseases like systemic lupus erythematosus. We present a rare case of APS with multiple finger gangrene post-intravenous cannulation There were several challenges in establishing the diagnosis and treating the patient with surgery when urgent blood thinning was required. A detailed analysis of history and focused investigations would be required to prevent such complications in these patients.