Kinetic Analysis of Solute‐Solvent Partitioning During Saline Jet Nebulization

ABSTRACT Although jet nebulization has been extensively studied at the droplet level, time‐resolved, molecular‐level bulk liquid characterization has received relatively little attention. Here, we quantify solution, solvent, and mass loss rates in aqueous NaCl solutions over 300 s of jet nebulization operating at a defined set of conditions. Gravimetric and conductivity measurements indicate that solution and solvent masses decrease at effectively constant rates, independent of NaCl concentration. In contrast, solute nebulization rate strongly correlates with initial NaCl concentration, proceeding via fractional, pseudo‐first order kinetics. Together, the data support a dual‐pathway model that explains compositional drift during jet nebulization. These findings carry practical implications for aerosol science while expanding the fundamental understanding of atomization.

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Publication Details

Journal
International Journal of Chemical Kinetics
Published
2026-08-21
DOI
https://doi.org/10.1002/kin.70136
Primary Topic
Inhalation and Respiratory Drug Delivery
Type
article
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article

Kinetic Analysis of Solute‐Solvent Partitioning During Saline Jet Nebulization

Jeremy Carr, J. W. Carr, Darby L. Green, Kaitlyn R. Bell
International Journal of Chemical Kinetics
Inhalation and Respiratory Drug Delivery
article

Kinetic Analysis of Solute‐Solvent Partitioning During Saline Jet Nebulization

Jeremy Carr, J. W. Carr, Darby L. Green, Kaitlyn R. Bell
article en

Abstract

ABSTRACT Although jet nebulization has been extensively studied at the droplet level, time‐resolved, molecular‐level bulk liquid characterization has received relatively little attention. Here, we quantify solution, solvent, and mass loss rates in aqueous NaCl solutions over 300 s of jet nebulization operating at a defined set of conditions. Gravimetric and conductivity measurements indicate that solution and solvent masses decrease at effectively constant rates, independent of NaCl concentration. In contrast, solute nebulization rate strongly correlates with initial NaCl concentration, proceeding via fractional, pseudo‐first order kinetics. Together, the data support a dual‐pathway model that explains compositional drift during jet nebulization. These findings carry practical implications for aerosol science while expanding the fundamental understanding of atomization.

International Journal of Chemical Kinetics
Central Alabama Community College (US)
Clean water and sanitation
Openalex Percentile: Top 10%
Inhalation and Respiratory Drug Delivery
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Kinetic Analysis of Solute‐Solvent Partitioning During Saline Jet Nebulization — Jeremy Carr, J. W. Carr, et al. · International Journal of Chemical Kinetics (2026) | TGRS Research Map | TGRS