Trial-aligned associations between Neuropixels proxies and surface EEG during cortical stimulation in head-fixed mice

This preprint tests whether Neuropixels-derived population summaries covary with surface EEG features during cortical stimulation in head-fixed mice. Across 24 sessions from 23 mice, two nominally trial-aligned associations were identified: LFP standard deviation with EEG standard deviation, and spike rate with EEG spectral entropy. Both survived predefined sensitivity analyses and subject-level null controls. Cross-modal alignment remained unvalidated, artifact and common-driver controls were incomplete, and the exploratory state contrast does not establish causality or mechanism.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-08-21
DOI
https://doi.org/10.5281/zenodo.22041386
Primary Topic
Neural dynamics and brain function
Type
preprint
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preprint

Trial-aligned associations between Neuropixels proxies and surface EEG during cortical stimulation in head-fixed mice

Robin Langell
Zenodo (CERN European Organization for Nuclear Research)
Neural dynamics and brain function
preprint

Trial-aligned associations between Neuropixels proxies and surface EEG during cortical stimulation in head-fixed mice

Robin Langell
preprint en

Abstract

This preprint tests whether Neuropixels-derived population summaries covary with surface EEG features during cortical stimulation in head-fixed mice. Across 24 sessions from 23 mice, two nominally trial-aligned associations were identified: LFP standard deviation with EEG standard deviation, and spike rate with EEG spectral entropy. Both survived predefined sensitivity analyses and subject-level null controls. Cross-modal alignment remained unvalidated, artifact and common-driver controls were incomplete, and the exploratory state contrast does not establish causality or mechanism.

Zenodo (CERN European Organization for Nuclear Research)
Kemakta Konsult (SE)
Neural dynamics and brain function
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