Iron-Mediated N-Nitrosation of Secondary Amines under Ambient Conditions via a Nitrate Reduction Strategy

An efficient protocol for the synthesis of N-nitrosamines from secondary amines was developed utilizing iron(III) nitrate and sodium metabisulfite. The transformation proceeds via a nitrate-reduction strategy at room temperature in acetonitrile, affording N-nitrosamine products in good to excellent yields (75-93%). This methodology offers improved operational safety, faster reaction times, and a broad substrate scope.