Vascular-Written Neural Pathway: State-Gated Neurovascular Developmental Regeneration

This Version 2 proposal treats spinal cord injury as a constrained developmental territory rather than asking an artificial scaffold to prescribe the final axonal route. A sparse directional braid and an interconnected anisotropic porous matrix define a search space in which endothelial sprouts explore, connect, perfuse, stabilize, and undergo pruning. The primary hypothesis is that the pre-neural survival history and graph topology of a perfused vascular network will predict subsequent axonal trajectories more strongly than vessel density alone. Only after predefined vascular-function and safety thresholds are passed—the “Perfusion License”—is the neural phase initiated. The proposal distinguishes vascular quantity from vascular function, connectivity, and persistence; structural guidance from living perfusion; and elapsed-time staging from measured state-gated progression. It provides falsifiable hypotheses, experimental groups, provisional measurement gates, prospective prediction tests, and failure criteria for controlled in vitro or ex vivo investigation before any ethically approved animal study. This is an open, unvalidated preclinical research hypothesis. It does not claim a clinical treatment, demonstrated efficacy, world-first status, patentability, or a manufacturing or surgical protocol.