Primary Localized Amyloidosis of the Nasopharynx: A Case Report

Amyloidosis is characterized by the extracellular deposition of abnormally folded proteins. While localized forms occur in the head and neck, nasopharyngeal involvement is rare and can mimic malignancies.We present a rare case of primary localized nasopharyngeal amyloidosis. A 67-year-old female presented with nasal congestion, throat lump sensation, and left-sided conductive hearing loss. Endoscopy revealed a yellow-colored mass in the left nasopharynx. MRI showed a homogeneously enhancing lesion without destruction. Diagnosis was confirmed by histopathology demonstrating apple-green birefringence with Congo red staining. Systemic amyloidosis was excluded through comprehensive evaluation. The patient was managed with close follow-up, and no progression was observed over five years.Nasopharyngeal amyloidosis should be considered in the differential diagnosis of nasopharyngeal masses. Histopathological confirmation is essential, and systemic involvement must be meticulously excluded.