Biological Associative Memory Learning Control System Based on DNA Strand Displacement

Abstract In recent years, artificial intelligence technology, inspired by biology, has combined control systems with associative memory to simulate human learning and memory processes. The utilization of DNA strand displacement (DSD) technology has demonstrated significant advantages in solving problems in biocomputing and control systems. In this study, the forget system, input system and output system are designed based on DSD technology. A biological associative memory learning control system is constructed by cascading three DNA control system modules. Furthermore, a multi-input biological associative memory learning control system is extended to implement the basic functions of biological associative memory, including acquisition learning, differentiation learning, generalization learning and repetition learning. Additionally, different emotional stimuli are introduced into the multi-input biological associative memory learning control system to examine the varying effects of emotional stimuli on differentiation learning and generalization learning. This work provides a direction for the integration of biocomputing and control system.

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Publication Details

Journal
ACS Synthetic Biology
Published
2026-08-20
DOI
https://doi.org/10.1021/acssynbio.6c00507
Primary Topic
DNA and Biological Computing
Type
article
Field-Weighted Citation Impact
0.00

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article

Biological Associative Memory Learning Control System Based on DNA Strand Displacement

Junwei Sun, Pengpeng Zhao, Fei Fan, Yanfeng Wang et al.
ACS Synthetic Biology
DNA and Biological Computing
article

Biological Associative Memory Learning Control System Based on DNA Strand Displacement

Junwei Sun, Pengpeng Zhao, Fei Fan, Yanfeng Wang, Zicheng Wang
article en

Abstract

Abstract In recent years, artificial intelligence technology, inspired by biology, has combined control systems with associative memory to simulate human learning and memory processes. The utilization of DNA strand displacement (DSD) technology has demonstrated significant advantages in solving problems in biocomputing and control systems. In this study, the forget system, input system and output system are designed based on DSD technology. A biological associative memory learning control system is constructed by cascading three DNA control system modules. Furthermore, a multi-input biological associative memory learning control system is extended to implement the basic functions of biological associative memory, including acquisition learning, differentiation learning, generalization learning and repetition learning. Additionally, different emotional stimuli are introduced into the multi-input biological associative memory learning control system to examine the varying effects of emotional stimuli on differentiation learning and generalization learning. This work provides a direction for the integration of biocomputing and control system.

ACS Synthetic Biology
Zhengzhou University of Light Industry (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 16%
DNA and Biological Computing
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