Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation
Background: Diastolic dysfunction is a recognized chronic allograft complication, and a restrictive left ventricular filling pattern is associated with adverse outcomes. However, the underlying pathophysiological mechanisms remain unclear.
Authors
- Tomohito Ohtani (ORCID: https://orcid.org/0000-0002-2963-7895)
- Yuki Kuramoto (ORCID: https://orcid.org/0000-0001-7368-3584)
- Yasuhiro Akazawa (ORCID: https://orcid.org/0000-0002-0809-8714)
- Yasumasa Tsukamoto (ORCID: https://orcid.org/0000-0002-0963-6940)
- Kei Nakamoto
- Tatsuya Shiraki (ORCID: https://orcid.org/0000-0003-1901-1642)
- Yusuke Adachi (ORCID: https://orcid.org/0000-0001-7700-5916)
- Hidetaka Kioka (ORCID: https://orcid.org/0000-0002-5534-9272)
- Tomoyo Hamana (ORCID: https://orcid.org/0009-0005-0013-3166)
- Kosuke Takahari (ORCID: https://orcid.org/0000-0002-7887-7940)
- Yasuharu Takeda (ORCID: https://orcid.org/0000-0002-6389-1504)
- Hibiki Mima
- Daisuke Nakamura
- Isamu Mizote
- Shigeru Miyagawa
- Fusako Sera
- Yasushi Sakata
Institutions
- University of Fukui (JP)
- Hiroshima University (JP)
- National Cerebral and Cardiovascular Center (JP)
- Prime University (BD)
- Osaka Hospital (JP)
- Kobe University (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Circulation Journal
- Published
- 2026-08-20
- DOI
- https://doi.org/10.1253/circj.cj-26-0427
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00