Variability in recommending epilepsy surgery across Level IV epilepsy centers in the United States

OBJECTIVE: Surgery is an effective, yet underutilized treatment for children with drug-resistant epilepsy. Although predictors of surgical outcomes are well described, the decision to recommend surgery varies by institution. We aim to evaluate the rates of not recommending surgery, identify associated patient characteristics, and quantify variability across centers. METHODS: We queried the Pediatric Epilepsy Research Consortium Surgery database, a prospective multicenter cohort of children (0-18 years) undergoing initial evaluation for epilepsy surgery. Patients with documented surgical decisions were included. Demographic, clinical, and presurgical evaluation variables were compared by surgical recommendation status. Logistic regression identified factors associated with not recommending surgery. Mixed-effects models quantified between-center variability. RESULTS: Among 2480 patients across 29 centers, 532 (21%) were not recommended epilepsy surgery (median center rate 17%, interquartile range [IQR] 10%-28%). After accounting for patient characteristics associated with surgical candidacy, substantial variation in decision-making remained across centers, with a median twofold difference in the odds of not recommending surgery between otherwise similar patients evaluated at different institutions (Median Odds Ratio = 2.25; Intraclass Correlation Coefficient = .18). The clinical characteristics most strongly associated with not recommending surgery included monthly or less frequent seizures (odds ratio [OR] 2.17, 95% confidence interval [CI] 1.75-2.69), non-structural etiology (OR 2.02, 95% CI 1.56-2.61), and taking ≤2 anti-seizure medications (ASMs) (OR 1.67, 95% CI 1.34-2.08, all p's < .01). These characteristics showed minimal clustering across centers (ICCs < .05). SIGNIFICANCE: One in five children evaluated for epilepsy surgery are not recommended to pursue surgical treatment. Although clinical factors influence decision-making, they do not explain the substantial variation in recommendations across pediatric epilepsy centers. Similar children evaluated at different institutions had significant differences in the odds of not being recommended surgery, suggesting that institutional decision-making contributes importantly to surgical candidacy.

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Publication Details

Journal
Epilepsia
Published
2026-08-20
DOI
https://doi.org/10.1002/epi.70440
Primary Topic
Epilepsy research and treatment
Type
article
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article

Variability in recommending epilepsy surgery across Level IV epilepsy centers in the United States

Kristen H. Arredondo, Zachary M. Grinspan, Janelle L. Wagner, Cemal Karakas et al.
Epilepsia
Epilepsy research and treatment
article

Variability in recommending epilepsy surgery across Level IV epilepsy centers in the United States

Kristen H. Arredondo, Zachary M. Grinspan, Janelle L. Wagner, Cemal Karakas, Pradeep Javarayee, Ahmad Marashly, Michael Scott Perry, Steven M. Wolf, Pilar Pichon, Andrew Knox, Debopam Samanta, Krista Eschbach, Adam P. Ostendorf, Taylor J. Abel, Nancy A. McNamara, Danilo Bernardo, Jenny Lin, Jeffrey B. Bolton, Lily C. Wong-Kisiel, J. Coryell, Michael A. Ciliberto, Dewi F. Depositario‐Cabacar, Kurtis I. Auguste, Avery R. Caraway, Edward J. Novotny, the rest of the PERC Surgery Special Interest Group, Rani K. Singh, Shilpa B. Reddy, Dallas M. Armstrong, Fernando N. Galan
article en

Abstract

OBJECTIVE: Surgery is an effective, yet underutilized treatment for children with drug-resistant epilepsy. Although predictors of surgical outcomes are well described, the decision to recommend surgery varies by institution. We aim to evaluate the rates of not recommending surgery, identify associated patient characteristics, and quantify variability across centers. METHODS: We queried the Pediatric Epilepsy Research Consortium Surgery database, a prospective multicenter cohort of children (0-18 years) undergoing initial evaluation for epilepsy surgery. Patients with documented surgical decisions were included. Demographic, clinical, and presurgical evaluation variables were compared by surgical recommendation status. Logistic regression identified factors associated with not recommending surgery. Mixed-effects models quantified between-center variability. RESULTS: Among 2480 patients across 29 centers, 532 (21%) were not recommended epilepsy surgery (median center rate 17%, interquartile range [IQR] 10%-28%). After accounting for patient characteristics associated with surgical candidacy, substantial variation in decision-making remained across centers, with a median twofold difference in the odds of not recommending surgery between otherwise similar patients evaluated at different institutions (Median Odds Ratio = 2.25; Intraclass Correlation Coefficient = .18). The clinical characteristics most strongly associated with not recommending surgery included monthly or less frequent seizures (odds ratio [OR] 2.17, 95% confidence interval [CI] 1.75-2.69), non-structural etiology (OR 2.02, 95% CI 1.56-2.61), and taking ≤2 anti-seizure medications (ASMs) (OR 1.67, 95% CI 1.34-2.08, all p's < .01). These characteristics showed minimal clustering across centers (ICCs < .05). SIGNIFICANCE: One in five children evaluated for epilepsy surgery are not recommended to pursue surgical treatment. Although clinical factors influence decision-making, they do not explain the substantial variation in recommendations across pediatric epilepsy centers. Similar children evaluated at different institutions had significant differences in the odds of not being recommended surgery, suggesting that institutional decision-making contributes importantly to surgical candidacy.

Epilepsia
University of Iowa (US), George Washington University Hospital (US), Boston Children's Hospital (US), Children's Hospital of Orange County (US), Nationwide Children's Hospital (US), Primary Children's Hospital (US), Mayo Clinic (US), Children's National (US), University of Wisconsin–Madison (US), Johns Hopkins University (US), Medical University of South Carolina (US), University of California, San Francisco (US), New York Medical College (US), Medical College of Wisconsin (US), Cornell University (US), Johns Hopkins Medicine (US), Norcliffe Foundation (US), Cook Children's Medical Center (US), Children's Hospital Colorado (US), Monroe Carell Jr. Children's Hospital (US), Dell Children's Medical Center of Central Texas (US), Levine Children's Hospital (US), Beaumont Hospital, Royal Oak (US), University of Pittsburgh Medical Center (US), Mayo Clinic in Florida (US), Children's Healthcare of Atlanta (US), Iowa City Public Library (US), Beaumont Hospital, Troy (US), University of Arkansas for Medical Sciences (US), The University of Texas Southwestern Medical Center (US), University of Colorado Denver (US)
Peace, Justice and strong institutions
Openalex Percentile: Top 9%
Epilepsy research and treatment
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