The effect of biologics on pulmonary function tests and small airways in patients with severe asthma: a real-life study

INTRODUCTION: Significant advances have been made in the treatment and management of severe asthma with the development of biological treatments. OBJECTIVE: The aim of this study was to investigate changes in lung function tests potentially reflecting distal airflow limitation in patients with T2-high severe asthma treated with biological agents. METHODS: = 9 (11.2%)) for at least 1 year. The demographic data, comorbid diseases, asthma control test (ACT) scores, exacerbation rates, and pulmonary function test results of the patients were evaluated retrospectively. RESULTS: < 0.05). CONCLUSION: In conclusion, the findings of this study support that biologics were associated with improvements in spirometric parameters potentially reflecting distal airflow limitation.