Prognostic Impact of Sequential Measurable Residual Disease and KIT Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia: A Retrospective Multicenter Study of the Taiwan Pediatric Oncology Group

Background: variants in pediatric CBF-AML. Methods: We retrospectively analyzed 112 children with CBF-AML. We assessed MRD in bone marrow samples collected at diagnosis, the end of induction (EOI), the end of second consolidation (EO2C), and the end of consolidation (EOC) using quantitative reverse transcription PCR with TaqMan assays targeting two fusion transcripts. Results: variant, those who achieved MRD of ≥ 4-LR at EOC had significantly more favorable outcomes. Conclusions: variant status with MRD assessment provides additional prognostic value during treatment.

Authors

Institutions

Publication Details

Journal
Annals of Laboratory Medicine
Published
2026-08-19
DOI
https://doi.org/10.3343/alm.2025.0573
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Prognostic Impact of Sequential Measurable Residual Disease and KIT Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia: A Retrospective Multicenter Study of the Taiwan Pediatric Oncology Group

Jen‐Yin Hou, Shih‐Hsiang Chen, Fang‐Liang Huang, Tang‐Her Jaing et al.
Annals of Laboratory Medicine
Acute Myeloid Leukemia Research
article

Prognostic Impact of Sequential Measurable Residual Disease and KIT Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia: A Retrospective Multicenter Study of the Taiwan Pediatric Oncology Group

Jen‐Yin Hou, Shih‐Hsiang Chen, Fang‐Liang Huang, Tang‐Her Jaing, Shyh‐Shin Chiou, Ting‐Chi Yeh, Lee‐Yung Shih, Shih‐Chung Wang, Hsi‐Che Liu, Shang‐Hsien Yang, Ting‐Yu Huang, Chih‐Cheng Hsiao, Pei‐Chin Lin, Chao-Ping Yang
article en

Abstract

Background: variants in pediatric CBF-AML. Methods: We retrospectively analyzed 112 children with CBF-AML. We assessed MRD in bone marrow samples collected at diagnosis, the end of induction (EOI), the end of second consolidation (EO2C), and the end of consolidation (EOC) using quantitative reverse transcription PCR with TaqMan assays targeting two fusion transcripts. Results: variant, those who achieved MRD of ≥ 4-LR at EOC had significantly more favorable outcomes. Conclusions: variant status with MRD assessment provides additional prognostic value during treatment.

Annals of Laboratory Medicine
Kaohsiung Medical University (TW), Chang Gung University (TW), Mackay Memorial Hospital (TW), Chang Gung Memorial Hospital (TW), Taichung Veterans General Hospital (TW), Kaohsiung Chang Gung Memorial Hospital (TW), Linkou Chang Gung Memorial Hospital (TW), Hualien Tzu Chi Medical Center (TW), Chang Gung Children's Hospital (TW), Changhua Christian Hospital (TW)
Ministry of Health and Welfare, Ministry of Health and Welfare
Zero hunger
Openalex Percentile: Top 10%
Acute Myeloid Leukemia Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.