European Standard Clinical Practice Recommendations for Olfactory Neuroblastoma in Children and Adolescents: An Updated Consensus by the Expert Group
Pediatric very rare tumors (VRTs) are a highly heterogeneous group of neoplasms defined by an annual incidence of <2 cases per million children under 18 years. Their rarity precludes prospective clinical trials, resulting in limited evidence-based guidelines and largely individualized treatment approaches. Olfactory neuroblastoma (ON) is an exceptionally rare pediatric VRT arising from the olfactory neuroepithelium, typically affecting adults. In children, ON is locally aggressive and may present with regional or distant metastases. Prognosis depends on stage, histology, and multimodal treatment. Owing to the absence of pediatric-specific guidelines, this project aims to develop internationally harmonized consensus recommendations for diagnosis and management.
Authors
- Benoît Dumont (ORCID: https://orcid.org/0000-0001-8331-3480)
- Yves Réguerre (ORCID: https://orcid.org/0000-0001-7192-046X)
- Marco Ferrari (ORCID: https://orcid.org/0000-0002-4023-0121)
- Brice Fresneau (ORCID: https://orcid.org/0000-0001-7603-7828)
- Romain Luscan (ORCID: https://orcid.org/0000-0003-1219-727X)
- Calogero Virgone (ORCID: https://orcid.org/0000-0002-3651-9416)
- Daniel Orbach (ORCID: https://orcid.org/0000-0002-2520-139X)
- Rajkumar Venkatramani (ORCID: https://orcid.org/0000-0002-4785-106X)
- Giulia Fichera (ORCID: https://orcid.org/0000-0003-2977-5304)
- Enrico Pozzo (ORCID: https://orcid.org/0000-0002-3362-3509)
- Jelena Roganović
- Barbara Hero (ORCID: https://orcid.org/0000-0003-4129-890X)
- Daniela Di Carlo (ORCID: https://orcid.org/0000-0003-0573-8576)
- Anna Synakiewicz (ORCID: https://orcid.org/0000-0001-6418-0360)
- Gianni Bisogno (ORCID: https://orcid.org/0000-0003-4462-5523)
- Ewa Bień (ORCID: https://orcid.org/0000-0002-2091-2686)
- Elisabetta Zanoletti (ORCID: https://orcid.org/0000-0001-5562-5292)
- Andrea C. Ferrari (ORCID: https://orcid.org/0000-0002-4724-0517)
- Dominik T. Schneider (ORCID: https://orcid.org/0000-0001-8153-1601)
- Malgorzata A. Krawczyk
- Apostolos Pourtsidis
- Rita Alaggio
- Ines Brecht
- Jan Godzinski
- Tal Ben‐Ami
- Nuno Jorge do Reis Farinha
- Beate Timmermann
- Antoine Moya‐Plana
Institutions
- Hôpital Necker-Enfants Malades (FR)
- University of Padua (IT)
- German Cancer Research Center (DE)
- Kaplan Medical Center (IL)
- Institut Gustave Roussy (FR)
- Hospital de São João (PT)
- Szpital im Tadeusza Marciniaka (PL)
- West Cancer Center (US)
- Istituto Oncologico Veneto (IT)
- Bambino Gesù Children's Hospital (IT)
- Centre de Recherche en Cancérologie de Lyon (FR)
- University Children's Hospital Tübingen (DE)
- Klinikum Dortmund (DE)
- Mitera Hospital (GR)
- Children's Hospital Zagreb (HR)
- STZ eyetrial (DE)
- Centre Hospitalier Saint-Denis (FR)
- Azienda Ospedale - Università Padova (IT)
- Texas Children's Hospital (US)
- University Hospital Cologne (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- West German Heart and Vascular Center Essen (DE)
- Gdańsk Medical University (PL)
- Institut Curie (FR)
- University of Tübingen (DE)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-08-18
- DOI
- https://doi.org/10.1002/1545-5017.70527
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 0.00