Guideline for the Evaluation of Biobank Collections

INTRODUCTION: Biobank collections are a fundamental pillar for translational biomedical research and significantly contribute to the improvement of healthcare. To ensure the long-term continuity of these collections, it is essential to strike a balance between the financial, societal, and operational aspects of the collections. METHODS: This paper provides advice for a guideline that outlines how to achieve this balance via periodic or interim evaluations of biobank collections by assessing their suitability for scientific research ("Specimen and Data Considerations") and their scientific potential ("Institutional Value and Resource Considerations"). RESULTS: The result of a periodic or interim evaluation is a combination of suitability ("Specimen and Data Considerations"-(meta)data, ethical-legal considerations, biological material) and the purpose of the biobank collection ("Institutional Value and Resource Considerations"-value, use, available resources). The presented guideline offers comprehensive directions and considerations to assist in making informed decisions regarding the retention, transfer, or termination of a biobank collection. DISCUSSION: Regular evaluations of biobank collections are necessary to ensure their value for scientific research. A well-balanced approach ensures the continuous availability of sufficient, high-quality research biomaterials and associated data and their careful handling. This balance is important for advancing scientific progress, ultimately resulting in a better understanding of disease and new opportunities for prevention, diagnosis, and treatment.