Atypical Lentiginous Melanocytic Proliferations Case Series: Relationship to Type <scp>II</scp> Dysplastic Nevi and Lentiginous Melanoma
A recent study described a distinctive subset of dysplastic nevi in older patients, genetically characterized by non-BRAFV600E driver mutations and frequent TERT promoter mutations. It has been proposed that these lesions overlap with the so-called lentiginous dysplastic nevi of the elderly. We explore this relationship in a series of 24 atypical lentiginous melanocytic proliferations, correlating with ex vivo dermoscopy, as well as immunohistochemical and molecular findings. We also discuss the utility of the MPATH-Dx tool to improve consensus for such lesions.
Authors
- Maged Daruish (ORCID: https://orcid.org/0000-0001-9090-6380)
- Siebe Loontiens (ORCID: https://orcid.org/0000-0002-4602-4580)
- Joni Van der Meulen (ORCID: https://orcid.org/0000-0002-1916-2769)
- Marc Haspeslagh (ORCID: https://orcid.org/0009-0002-8843-9992)
- Julie Lemahieu (ORCID: https://orcid.org/0000-0003-3942-6669)
- Saleem Taibjee
- Boris C. Bastian
- Laura Gadeyne
- Ella De Ryck
Institutions
- University of California, San Francisco (US)
- Ghent University Hospital (BE)
- Cancer Research UK (GB)
- Ghent University (BE)
- Cancer Research Institute Ghent (BE)
- Dorset County Hospital (GB)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
Publication Details
- Journal
- Journal of Cutaneous Pathology
- Published
- 2026-08-18
- DOI
- https://doi.org/10.1111/cup.70198
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00