A Strong, Water‐Retaining and Wide‐Temperature Suitable Biomass‐Based Adhesive Inspired by Setae and Biomineralization

ABSTRACT Bio‐based adhesives are gaining traction by virtue of their tremendous potential for substituting petrochemical adhesives, yet the restricted adhesion performance, poor water retention, and intrinsic flammability severely hindered their scale‐up application. Herein, drew inspiration from gecko setae and biomineralization, a novel bio‐based adhesive derived from epoxidized HEC‐core hyperbranched polyester hybrid (EH), gelatin (G) and modified nano‐hydroxyapatite (γHA) is presented. In this system, the self‐synthesized EH features a setae‐like hyperbranched structure enriched with abundant active groups, which maximize interfacial effectiveness. Meanwhile the gelatin and hydroxyapatite act synergistically achieve marked enhancements in robust cohesion and durable water retention via biomineralization. The developed organic‐inorganic hybrid adhesive offers a unique combination of broad substrate universality, low‐temperature curability, satisfactory flame retardancy, outstanding environmental robustness, and superior storage stability. The integrated performance profile enables wide‐temperature on‐demand bonding, safe construction application, and extended practical utility with reliable long‐term performance. This bioinspired strategy represents a fresh and feasible insight for the promotion of bio‐based adhesive, and offers a prospective pathway toward robust, sustainable, and safety versatile bonding materials.