Ketamine and esketamine for postoperative analgesia in gynaecological surgery

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: The primary objective of this review is to evaluate the benefits and harms of a subanaesthetic dosage of ketamine/esketamine as an adjunct to perioperative analgesia versus standard analgesia or placebo for reducing postoperative pain in participants undergoing gynaecological surgical procedures. A secondary objective is to assess whether these outcomes differ by type of surgery, background condition, type of drug used (ketamine or esketamine), dosage, and presence of preoperative chronic pain or preoperative long-term or recurrent opioid use.

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Publication Details

Journal
Cochrane Database of Systematic Reviews
Published
2026-08-18
DOI
https://doi.org/10.1002/14651858.cd016377
Primary Topic
Treatment of Major Depression
Type
article
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article

Ketamine and esketamine for postoperative analgesia in gynaecological surgery

Martin F. Bjurström, Silvia Marchesi, Peter Bentzer, I. Soumpasis et al.
Cochrane Database of Systematic Reviews
Treatment of Major Depression
article

Ketamine and esketamine for postoperative analgesia in gynaecological surgery

Martin F. Bjurström, Silvia Marchesi, Peter Bentzer, I. Soumpasis, Jaquette Liljencrantz, Emma Sinervo, Anca Cristina Balintescu, Said Makari
article en

Abstract

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: The primary objective of this review is to evaluate the benefits and harms of a subanaesthetic dosage of ketamine/esketamine as an adjunct to perioperative analgesia versus standard analgesia or placebo for reducing postoperative pain in participants undergoing gynaecological surgical procedures. A secondary objective is to assess whether these outcomes differ by type of surgery, background condition, type of drug used (ketamine or esketamine), dosage, and presence of preoperative chronic pain or preoperative long-term or recurrent opioid use.

Cochrane Database of Systematic ReviewsVol. 2026(8)
Uppsala University (SE), Uppsala University Hospital (SE), Malmö University (SE), Karolinska Institutet (SE), Stockholm South General Hospital (SE), Skåne University Hospital (SE), Centre for Palaeogenetics (SE), University of Gothenburg (SE)
Good health and well-being
Openalex Percentile: Top 11%
Treatment of Major Depression
DOISourceOpenAlex
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Ketamine and esketamine for postoperative analgesia in gynaecological surgery — Martin F. Bjurström, Silvia Marchesi, et al. · Cochrane Database of Systematic Reviews (2026) | TGRS Research Map | TGRS