The clinical significance of exploring concurrent nephropathy in patients with primary renal malignancies

BACKGROUND: This study aimed to compare the clinicopathological features and clinical outcomes between patients with primary renal malignancies with pathologically diagnosed nephropathy (PRMN) and those with isolated primary renal malignancies (IPRMs). METHODS: We enrolled 31 patients with PRMN and 31 matched controls with IPRM between 2013 and 2023. Clinical characteristics, tumour pathological features, therapeutic interventions and prognostic outcomes were systematically analysed. Nephropathy was diagnosed by immunofluorescence, immunohistochemistry and light microscopy. RESULTS: = 0.038), though this finding requires validation. CONCLUSIONS: Patients with PRMN exhibited distinct clinicopathological characteristics, factors associated with disease progression, and a higher incidence of adverse outcomes compared to those with IPRM.