Palmatine Induces TNNT1 Ubiquitination and Degradation to Potentiate Ferroptosis Sensitivity in Hepatocellular Carcinoma
Ferroptosis, an iron-dependent form of regulated cell death, serves as an important mechanism associated with cancer progression. Natural compounds, particularly alkaloids, have emerged as attractive candidates for regulating ferroptotic cell death, thereby providing a promising anticancer strategy. However, the molecular mechanisms underlying their antitumor effects remain poorly understood. In this study, we aimed to investigate the antitumor effects and underlying mechanisms of natural alkaloids against HCC.
Authors
- Shangjun Zhou
- Xiaokang Wang (ORCID: https://orcid.org/0000-0002-4325-9907)
- Zhiyang Zhou (ORCID: https://orcid.org/0000-0002-3722-9808)
- Fanci Xie
- Zhijie Xu
- Chunhua Wang
- Jiayu Wang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Central South University (CN)
- Longgang Central Hospital (CN)
- Hunan Cancer Hospital (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
- Tokushima University (JP)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2026-08-19
- DOI
- https://doi.org/10.14218/jcth.2026.00215
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province