Beyond Visual Scoring: Computational <scp> <b>CT</b> </scp> ‐analysis for <scp> <b>HRCT</b> </scp> based quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Interstitial lung disease (IRD-ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRD). High-resolution computed tomography (HRCT) is widely considered the gold standard for the non-invasive assessment of ILD; however, its interpretation is constrained by substantial inter-observer variability and the need for time-consuming expert evaluation. Computer-based image analysis including artificial intelligence (AI) has emerged as a promising approach for the automated, objective, and quantitative analysis of HRCT images. This method enables precise volumetric assessment of parenchymal alterations and facilitates pattern classification with unprecedented accuracy and efficiency. This review synthesises current evidence on computational driven HRCT quantification in IRD-ILD, highlighting available technical approaches, validation strategies, and clinical applications.

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Publication Details

Journal
Arthritis Care & Research
Published
2026-08-17
DOI
https://doi.org/10.1002/acr.80142
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
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article

Beyond Visual Scoring: Computational CT ‐analysis for HRCT based quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Tobias Hoffmann, Denise Beckmann, D Renz, Nicole Schadewaldt et al.
Arthritis Care & Research
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
article

Beyond Visual Scoring: Computational CT ‐analysis for HRCT based quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Tobias Hoffmann, Denise Beckmann, D Renz, Nicole Schadewaldt, Alexander Pfeil, Bianca Lassen-Schmidt, Ulf Teichgräber, Gunter Wolf
article en

Abstract

Interstitial lung disease (IRD-ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRD). High-resolution computed tomography (HRCT) is widely considered the gold standard for the non-invasive assessment of ILD; however, its interpretation is constrained by substantial inter-observer variability and the need for time-consuming expert evaluation. Computer-based image analysis including artificial intelligence (AI) has emerged as a promising approach for the automated, objective, and quantitative analysis of HRCT images. This method enables precise volumetric assessment of parenchymal alterations and facilitates pattern classification with unprecedented accuracy and efficiency. This review synthesises current evidence on computational driven HRCT quantification in IRD-ILD, highlighting available technical approaches, validation strategies, and clinical applications.

Arthritis Care & Research
Medizinische Hochschule Hannover (DE), University Hospital Münster (DE), Jena University Hospital (DE), Fraunhofer Institute for Digital Medicine (DE), Friedrich Schiller University Jena (DE)
Good health and well-being
Openalex Percentile: Top 10%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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