What my mother’s APOE result taught me about dementia risk

As genetic and biomarker-based dementia risk assessments become more widely used, the challenge is not only estimating risk, but returning it responsibly. Discussing my mother’s APOE genotype with her showed me how differently dementia risk can appear in a dataset, a family conversation, and lived experience. That lesson now shapes my work on integrated genetic–exposome risk assessments and return-of-results approaches.

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Publication Details

Journal
npj Dementia
Published
2026-08-18
DOI
https://doi.org/10.1038/s44400-026-00096-6
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

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article

What my mother’s APOE result taught me about dementia risk

Shea J. Andrews
npj Dementia
Dementia and Cognitive Impairment Research
article

What my mother’s APOE result taught me about dementia risk

Shea J. Andrews
article en

Abstract

As genetic and biomarker-based dementia risk assessments become more widely used, the challenge is not only estimating risk, but returning it responsibly. Discussing my mother’s APOE genotype with her showed me how differently dementia risk can appear in a dataset, a family conversation, and lived experience. That lesson now shapes my work on integrated genetic–exposome risk assessments and return-of-results approaches.

npj DementiaVol. 2(1)
University of California, San Francisco (US)
National Institutes of Health, National Institute on Aging
Gender equality
Openalex Percentile: Top 9%
Dementia and Cognitive Impairment Research
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