Much Ado About a Mutation: Congenital Melanocytic Nevus With <scp>LINC00518</scp> and Preferentially Expressed Antigen in Melanoma Positivity
Small and medium sized congenital melanocytic nevi (CMN) have an overall low risk of malignant potential. This case demonstrates a pediatric patient with a small CMN positive for LINC00518 (LINC) and preferentially expressed antigen in melanoma (PRAME) on a non-invasive molecular test not yet validated in children. Although her nevus had not evolved, the availability of a molecular test and curiosity ultimately raised concern about this otherwise reassuring, stable CMN. This demonstrates the pitfalls of non-invasive testing in pediatric patients with CMN.
Authors
- Elena B. Hawryluk (ORCID: https://orcid.org/0000-0002-0862-3339)
- Holly Neale (ORCID: https://orcid.org/0000-0003-0361-3657)
- Tatiana Abrantes
- Ingrid M. Ganske (ORCID: https://orcid.org/0000-0001-6751-6990)
- Birgitta Schmidt (ORCID: https://orcid.org/0000-0002-8438-4149)
- Racquel A. Bitar (ORCID: https://orcid.org/0009-0003-4466-1863)
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- University of Massachusetts Chan Medical School (US)
- Brown University (US)
- Massachusetts General Hospital (US)
- Boston Children's Museum (US)
- UMass Memorial Medical Center (US)
Publication Details
- Journal
- Pediatric Dermatology
- Published
- 2026-08-17
- DOI
- https://doi.org/10.1111/pde.70341
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00