Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2026.3.3
This guideline has been updated. This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the online dynamic version for the latest updates. Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual . ASCO Living Guidelines follow the ASCO Conflict of Interest Policy Implementation for Clinical Practice Guidelines . Living Guidelines and updates are not intended to substitute for independent professional judgment of the treating clinician and do not account for individual variation among patients. See appendix for disclaimers and other important information (Appendix I and Appendix II). Updates are published regularly and can be found on the ASCO Publications website .
Authors
- Parth Desai (ORCID: https://orcid.org/0000-0002-7715-4919)
- Kirstin Perdrizet (ORCID: https://orcid.org/0000-0002-8746-665X)
- Lyudmila Bazhenova (ORCID: https://orcid.org/0000-0001-8764-4359)
- Paul Wheatley‐Price (ORCID: https://orcid.org/0000-0002-3725-9767)
- Kristen Ashley Marrone (ORCID: https://orcid.org/0000-0001-5319-824X)
- Terri Conneran
- Hidehito Horinouchi (ORCID: https://orcid.org/0000-0001-9090-801X)
- Greg Andrew Durm (ORCID: https://orcid.org/0000-0003-2606-745X)
- Nofisat Ismaila (ORCID: https://orcid.org/0000-0003-2074-1896)
- Antonio Calles (ORCID: https://orcid.org/0000-0002-2547-1947)
- Swati Kulkarni
- Jeremy Cetnar
- Humera Khurshid
Institutions
- Western University (CA)
- Indiana University Health (US)
- Fox Chase Cancer Center (US)
- American Society of Clinical Oncology (US)
- Johns Hopkins University (US)
- University of Ottawa (CA)
- Oregon Health & Science University (US)
- Brown University (US)
- Ottawa Hospital (CA)
- Johns Hopkins Bayview Medical Center (US)
- Hospital General Universitario Gregorio Marañón (ES)
- University of California San Diego (US)
- Windsor Regional Hospital (CA)
- William Osler Health System (CA)
- Tokyo National Hospital (JP)
- Indiana University – Purdue University Indianapolis (US)
- University of San Francisco (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-08-17
- DOI
- https://doi.org/10.1200/jco-26-01958
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00