Recurrent multiple giant cystic-solid hemangioblastomas of the cerebellopontine angle with extension to both cerebellar hemispheres: a case report and literature review

Multiple giant cystic-solid hemangioblastomas arising in the cerebellopontine angle (CPA) and extending to both cerebellar hemispheres are exceedingly uncommon. We report the case of a 54-year-old female patient who was admitted with to the hospital with a two-month history of headache and hearing loss. On physical examination, the patient was alert, and Romberg’s sign was positive. Magnetic resonance imaging (MRI) revealed the presence of multiple irregular cystic-solid abnormal signal shadows in the right CPA and bilateral cerebellar hemispheres. Total tumor resection was performed via a midline suboccipital approach, resulting in marked relief of the patient’s headache symptoms and preservation of cranial nerve function. The diagnosis of hemangioblastoma was confirmed by postoperative immunohistochemical staining.

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Publication Details

Journal
Diagnostic Pathology
Published
2026-08-17
DOI
https://doi.org/10.1186/s13000-026-01840-5
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
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article

Recurrent multiple giant cystic-solid hemangioblastomas of the cerebellopontine angle with extension to both cerebellar hemispheres: a case report and literature review

Zihao Wang, Xiaochao Xia, Shixue Xia, Lvmeng Song et al.
Diagnostic Pathology
Cancer, Hypoxia, and Metabolism
article

Recurrent multiple giant cystic-solid hemangioblastomas of the cerebellopontine angle with extension to both cerebellar hemispheres: a case report and literature review

Zihao Wang, Xiaochao Xia, Shixue Xia, Lvmeng Song, Yinchuan Cheng, Ping Xiong, Shun Li, Shumin Wang, Jike Amu, Xia Wu
article en

Abstract

Multiple giant cystic-solid hemangioblastomas arising in the cerebellopontine angle (CPA) and extending to both cerebellar hemispheres are exceedingly uncommon. We report the case of a 54-year-old female patient who was admitted with to the hospital with a two-month history of headache and hearing loss. On physical examination, the patient was alert, and Romberg’s sign was positive. Magnetic resonance imaging (MRI) revealed the presence of multiple irregular cystic-solid abnormal signal shadows in the right CPA and bilateral cerebellar hemispheres. Total tumor resection was performed via a midline suboccipital approach, resulting in marked relief of the patient’s headache symptoms and preservation of cranial nerve function. The diagnosis of hemangioblastoma was confirmed by postoperative immunohistochemical staining.

Diagnostic Pathology
The First People's Hospital of Shunde (CN), Affiliated Hospital of North Sichuan Medical College (CN), First People's Hospital of Chongqing (CN), Gaozhou People's Hospital (CN), Xiang Yang No.1 People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 13%
Cancer, Hypoxia, and Metabolism
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Recurrent multiple giant cystic-solid hemangioblastomas of the cerebellopontine angle with extension to both cerebellar hemispheres: a case report and literature review — Zihao Wang, Xiaochao Xia, et al. · Diagnostic Pathology (2026) | TGRS Research Map | TGRS