Global genomic surveillance uncovers emergence and spatiotemporal patterns of World Health Organization priority antibiotic resistance in invasive Salmonella
Abstract Antimicrobial resistance (AMR) in invasive Salmonella infections remains a global public health concern, and enhanced high-quality genomic surveillance is essential to inform guidelines and policies. Here, we aimed to describe clinically key antibiotic resistance trends in invasive Salmonella infections using 7691 isolates derived from national surveillance and publicly available datasets between 1954 and 2024. 29 (37.7%) of 77 countries identified at least one isolate with resistance or decreased susceptibility to ciprofloxacin, 25 (32.5%) and 29 (37.7%) countries resistance or decreased susceptibility to ceftriaxone and cefixime, 8 (10.4%) countries resistance to azithromycin, 15 (19.5%) countries resistance to fosfomycin, 10 (13.0%) countries resistance to colistin. Overall, 7.39% of 7691 isolates were resistant or decreased susceptibility to ciprofloxacin, 7.91% reported resistance or decreased susceptibility to 3GCs, 4.23% reported resistance to fosfomycin, and 0.79% reported resistance to azithromycin. Globally, azithromycin resistance is increasing, as is resistance or decreased susceptibility to ciprofloxacin, 3GCs, and 4GCs. However, surveillance levels remain inadequate in African and South American regions. We generated a global map of clinically key antibiotic resistance genes in invasive Salmonella infections worldwide. This retrospective, global, longitudinal genomic epidemiology study on invasive Salmonella provides evidence-based data for clinical guidelines, genomic surveillance, AMR control, and public health policies.
Authors
- Mingliu Wang
- George F. Gao (ORCID: https://orcid.org/0000-0002-3869-615X)
- Jinhua Meng (ORCID: https://orcid.org/0009-0005-2387-8152)
- Chunmei Jing (ORCID: https://orcid.org/0009-0005-9930-3582)
- Mei Zeng
- Xuebin Xu (ORCID: https://orcid.org/0000-0002-1986-6539)
- Mengqi Qu (ORCID: https://orcid.org/0000-0002-3707-9870)
- Yufeng Qiu (ORCID: https://orcid.org/0000-0003-2842-6735)
- Yanan Wang (ORCID: https://orcid.org/0000-0002-7461-2195)
- Jiale Chen (ORCID: https://orcid.org/0000-0002-4819-4911)
- Sufang Ma
- Xiaolu Pang
- Hongxia Yang (ORCID: https://orcid.org/0000-0003-4538-264X)
- Meilian Huang
- Yuhang Pei
- Na Lyu
- Baoli Zhu (ORCID: https://orcid.org/0000-0001-5326-9503)
- Jiangtao Wang
- Yue Liu (ORCID: https://orcid.org/0009-0001-6279-7815)
- Chaochao Zhao
- Ziru Yang
- Yibin Zhou
- Wenqing Wang
- Wufuer. Xiayidan
Institutions
- Shanxi Medical University (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Chinese Academy of Sciences (CN)
- The Fourth People's Hospital (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- Education Department of Fujian Province (CN)
- Shanghai Pudong Institute of Education Development (CN)
- Guangxi Center for Disease Prevention and Control (CN)
- Shanxi Provincial Children's Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Shanghai Municipal Center For Disease Control Prevention (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
- University of Chinese Academy of Sciences (CN)
- Henan Agricultural University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-08-17
- DOI
- https://doi.org/10.1038/s41467-026-76354-1
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Henan Agricultural University
- National Key Research and Development Program of China