Total Synthesis of (+)-Psychotrimine and Formal Synthesisof (+)-Psychotetramine via Late-Stage Ni(II)-Photoredox N-Arylation
Abstract An efficient strategy for the total syntheses of architecturally complex alkaloids, (+)-psychotrimine (1), and formal synthesis of (+)-psychotetramine (2) has been achieved via late-stage Ni(II)-photoredox N-arylation. The method involves the formation of the key building blocks using mild indole addition to bromopyrroloindole and their assembly into the oligomeric hexahydropyrrolo[2,3-b]indole scaffolds via a blue LED-mediated metallaphotoredox-enabled C–N coupling reaction.
Authors
- Debabrata Mondal (ORCID: https://orcid.org/0009-0007-8834-7525)
- Alakesh Bisai (ORCID: https://orcid.org/0000-0001-5295-9756)
- Arindam Khatua (ORCID: https://orcid.org/0000-0001-5847-5090)
- Pranay Shyamal
- Satadru Dutta
Institutions
- Indian Institute of Science Education and Research Kolkata (IN)
- Indian Institute of Science Education and Research, Bhopal (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-08-17
- DOI
- https://doi.org/10.1021/acs.orglett.6c02081
- Primary Topic
- Advanced Synthetic Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Ministry of Education, India
- Science and Engineering Research Board