The Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions

Most psychedelic experiences occur outside clinical settings, yet as policy frameworks rapidly expand to accommodate nonclinical use, no systematic data exist on who seeks psychedelic support, under what circumstances, or what makes that support effective. We present the Fireside Database, a US-based dataset comprising 25,419 peer support interactions conducted by 220 trained volunteers at Fireside Project's Psychedelic Support Line between April 2021 and February 2026. The released resource integrates structured interaction logs with volunteer-coded metadata and 2777 caller satisfaction surveys across five outcome dimensions. Psilocybin was the most commonly reported substance (59.9% of coded interactions), while cannabis produced the highest distress rate (47.2%). The nested data structure-with 50 supporters each completing ≥10 surveyed interactions-supports multilevel modeling of individual supporter effects on caller outcomes. This resource enables research in psychedelic epidemiology, evidence-based training design, and the investigation of what makes psychedelic psychological support effective.

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Publication Details

Journal
Science Advances
Published
2026-10-30
DOI
https://doi.org/10.1126/sciadv.aeg4737
Primary Topic
Psychedelics and Drug Studies
Type
article
Field-Weighted Citation Impact
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article

The Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions

Marc Santolini, Mickaël Eskinazi, Joshua Theodore White, Félix Schoeller et al.
Science Advances
Psychedelics and Drug Studies
article

The Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions

Marc Santolini, Mickaël Eskinazi, Joshua Theodore White, Félix Schoeller, Dana Xiadani, Wesley Bellanca, David Esselman, Wyatt Houtz, Ashwin Murali
article en

Abstract

Most psychedelic experiences occur outside clinical settings, yet as policy frameworks rapidly expand to accommodate nonclinical use, no systematic data exist on who seeks psychedelic support, under what circumstances, or what makes that support effective. We present the Fireside Database, a US-based dataset comprising 25,419 peer support interactions conducted by 220 trained volunteers at Fireside Project's Psychedelic Support Line between April 2021 and February 2026. The released resource integrates structured interaction logs with volunteer-coded metadata and 2777 caller satisfaction surveys across five outcome dimensions. Psilocybin was the most commonly reported substance (59.9% of coded interactions), while cannabis produced the highest distress rate (47.2%). The nested data structure-with 50 supporters each completing ≥10 surveyed interactions-supports multilevel modeling of individual supporter effects on caller outcomes. This resource enables research in psychedelic epidemiology, evidence-based training design, and the investigation of what makes psychedelic psychological support effective.

Science AdvancesVol. 12(44)
University of Geneva (CH), Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Sorbonne Nouvelle (FR), Sorbonne Université (FR), Center for Research and Interdisciplinarity (FR), University Hospital of Geneva (CH), CY Cergy Paris Université (FR), Learning Transitions (FR), Université Paris 1 Panthéon-Sorbonne (FR)
Good health and well-being
Openalex Percentile: Top 39%
Psychedelics and Drug Studies
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The Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions — Marc Santolini, Mickaël Eskinazi, et al. · Science Advances (2026) | TGRS Research Map | TGRS