Site-SelectiveSequential Isocyanide Insertion atDual sp3- and sp2-Carbon Centers EnablesDivergent Access to N/O-Containing Heterocycles
Abstract The study reports a Pd-catalyzed chemoselective sequential isocyanide insertion at sp3- and sp2-carbon centers, which enables the controlled incorporation of two or four isocyanide units. This cascade process, derived from readily accessible Passerini adducts, provides a divergent platform for the rapid assembly of diverse N- and O-containing heterocycles. The strategy overcomes the limitations of single-site reactions and offers high selectivity and structural complexity in heterocycle synthesis.
Authors
- Peng Yang (ORCID: https://orcid.org/0000-0002-3645-6443)
- You Zhou (ORCID: https://orcid.org/0009-0007-5054-1875)
- Shanshan Liu (ORCID: https://orcid.org/0000-0002-2123-3634)
- Zi‐Qiang Wang
- Long Wang (ORCID: https://orcid.org/0000-0001-7548-014X)
- Zhi‐Lin Ren
- Ping He (ORCID: https://orcid.org/0000-0003-2081-4899)
- Ke-Ji Li
- Cheng-Cheng Ding
- Ying-Min Liu
Institutions
- China Three Gorges University (CN)
- Hubei University of Arts and Science (CN)
- Institute of New Materials (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-08-14
- DOI
- https://doi.org/10.1021/acs.orglett.6c03179
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province
- Hubei University of Arts and Science